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    HETRODIMERIC V-C-FC-V-C ANTIBODY
    3.
    发明公开
    HETRODIMERIC V-C-FC-V-C ANTIBODY 审中-公开

    公开(公告)号：EP3733710A1

    公开(公告)日：2020-11-04

    申请号：EP20165091.8

    申请日：2014-09-25

    申请人： Amgen, Inc

    发明人： MICHAELS, Mark L. ,  BORGES, Luis G. ,  YAN, Wei

    IPC分类号： C07K16/28 ,  C07K16/32

    摘要： Described herein is a dimeric, bispecific antibody format. Each polypeptide chain of the dimer comprises an immunoglobulin variable region, an immunoglobulin constant region, an Fc polypeptide chain, another immunoglobulin variable region, and another immunoglobulin constant region. Also described are methods of making and using such antibodies.

    ANTAGONISTS AND AGONISTS OF LDCAM AND METHODS OF USE
    8.
    发明公开
    ANTAGONISTS AND AGONISTS OF LDCAM AND METHODS OF USE 审中-公开
    拮抗剂和LDCAM激动剂及使用方法

    公开(公告)号：EP1648935A2

    公开(公告)日：2006-04-26

    申请号：EP04779057.1

    申请日：2004-07-23

    申请人： AMGEN INC.

    发明人： GALIBERT, Laurent, J. ,  YAN, Wei

    IPC分类号： C07K14/705

    CPC分类号： C07K16/2803 ,  C07K2319/30

    摘要： The invention pertains to agonists and antagonists of LDCAM and methods of treating disease and infection by administering one or more LDCAM antagonists or agonists. This abstract is provided for the sole purpose of enabling the reader to quickly ascertain the subject matter of the technical disclosure and is not intended to be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

    FC VARIANTS
    10.
    发明公开
    FC VARIANTS 有权
    FC-VARIANTEN

    公开(公告)号：EP2686345A1

    公开(公告)日：2014-01-22

    申请号：EP12711513.7

    申请日：2012-03-15

    申请人： Amgen Inc.

    发明人： LIU, Zhi ,  KANNAN, Gunasekaran ,  YAN, Wei

    IPC分类号： C07K16/00

    CPC分类号： C07K16/283 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/00 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732

    摘要： Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a similar Fc-containing protein comprising a wild type Fc region. Also disclosed are nucleic acids encoding such Fc-containing proteins, methods for making such proteins, and methods of treatment utilizing such proteins.

    摘要翻译： 公开了包含结合区和变体Fc区的含Fc蛋白，其可以比包含野生型Fc区的类似的含Fc蛋白更有效地引发一种或多种免疫效应子功能和/或与Fc受体结合。 还公开了编码这种含Fc蛋白质的核酸，制备这种蛋白质的方法，以及利用这种蛋白质的治疗方法。