公开(公告)号：EP2001844A2

公开(公告)日：2008-12-17

申请号：EP07752941.0

申请日：2007-03-12

申请人： Amgen, Inc

发明人： SHARMA, Rajiv ,  AKERMAN, Michelle ,  CARDOZO, Mario, G. ,  HOUZE, Jonathan, B. ,  LI, An-Rong ,  LIU, Jinqian ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio, C. ,  SCHMITT, Michael, J. ,  SUN, Ying ,  WANG, Yingcai ,  WANG, Zhongyu ,  ZHU, Liusheng

IPC分类号： C07D209/08 ,  C07D209/46 ,  C07D215/22 ,  C07D277/24 ,  C07D311/74 ,  C07D313/08 ,  C07D417/12 ,  C07D498/04 ,  C07C59/54 ,  C07C59/72 ,  A61K31/426 ,  A61P3/10

CPC分类号： C07C57/62 ,  C07C59/64 ,  C07C59/72 ,  C07D209/08 ,  C07D209/46 ,  C07D215/20 ,  C07D215/227 ,  C07D277/24 ,  C07D311/58 ,  C07D311/74 ,  C07D311/76 ,  C07D313/08 ,  C07D417/12 ,  C07D498/04

摘要： Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject formula (I) (II) where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.

公开(公告)号：EP1680114A2

公开(公告)日：2006-07-19

申请号：EP04796647.8

申请日：2004-10-27

申请人： AMGEN INC. ,  Japan Tobacco, Inc.

发明人： CARDOZO, Mario, G. ,  POWERS, Jay, P. ,  GOTO, Hiroyuki, c/o Japan Tobacco, Inc. ,  HARADA, Kazuhito, c/o Japan Tobacco, Inc. ,  IMAMURA, Katsuaki, c/o Japan Tobacco, Inc. ,  KAKUTANI, Makoto, c/o Japan Tobacco, Inc. ,  MATSUDA, Isamu, c/o Japan Tobacco, Inc. ,  OHE, Yasuhiro, c/o Japan Tobacco, Inc. ,  YATA, Shinji, c/o Japan Tobacco, Inc. ,  TU, Hua

IPC分类号： A61K31/445 ,  C07D401/04

CPC分类号： C07D401/12 ,  A61K31/18 ,  A61K31/4196 ,  A61K31/64 ,  A61K38/28 ,  A61K45/06 ,  C04B35/632 ,  C07D249/08 ,  C07D249/14 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D491/10

摘要： The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.

公开(公告)号：EP1556053A1

公开(公告)日：2005-07-27

申请号：EP03752410.5

申请日：2003-09-19

申请人： Amgen Inc.

发明人： BURKITT, Simon, A. ,  CARDOZO, Mario, G. ,  CUSHING, Timothy, D. ,  DEGRAFFENREID, Michael, R. ,  FARTHING, Christopher, N. ,  HAO, Xiaolin ,  JAEN, Juan, C. ,  JIAO, Xian, Yun ,  KOPECKY, David, J. ,  LABELLE, Marc ,  LIVELY, Sarah, E. ,  MCMINN, Dustin, L. ,  RASMUSSEN, Sven, P. ,  SHIN, Youngsook ,  SMITH, Andrew ,  SMITH, Marie-Louise

IPC分类号： A61K31/54

CPC分类号： C07D231/56 ,  C07D239/74 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/04

摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.