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公开(公告)号：EP3008039B1
公开(公告)日：2020-11-11
申请号：EP14735785.9
申请日：2014-06-09
申请人： AMGEN INC.
发明人： BIO, Matthew , CAILLE, Sebastien , COCHRAN, Brian , FANG, Yuanqing , FOX, Brian, M. , LUCAS, Brian, S. , MCGEE, Lawrence, R. , VOUNATSOS, Filisaty , WIEDEMANN, Sean , WORTMAN, Sarah
IPC分类号： C07D211/76 , A61K31/45 , A61P35/00 , C07C309/04 , C07D498/04
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2.发明授权CIS-MORPHOLINONE AND OTHER COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 有权CIS-吗啡酮和其他化合物作为MDM2抑制剂用于治疗癌症
公开(公告)号：EP2958902B1
公开(公告)日：2017-11-15
申请号：EP14708410.7
申请日：2014-02-18
申请人： Amgen Inc.
发明人： BARTBERGER, Michael, D. , BECK, Hilary, Plake , DEGRAFFENREID, Michael, R. , FOX, Brian, M. , GONZALEZ LOPEZ DE TURISO, Felix , JULIAN, Lisa, D. , KAYSER, Frank , MEDINA, Julio, C. , OLSON, Steven, H. , REW, Yosup , ROVETO, Philip, M. , SUN, Daqing , YAN, Xuelei
IPC分类号： C07D265/32 , C07D413/04 , C07D413/06 , C07D279/12 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P35/00
CPC分类号： C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D487/04
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公开(公告)号：EP3008039A1
公开(公告)日：2016-04-20
申请号：EP14735785.9
申请日：2014-06-09
申请人： AMGEN, INC.
发明人： BIO, Matthew , CAILLE, Sebastien , COCHRAN, Brian , FANG, Yuanqing , FOX, Brian, M. , LUCAS, Brian, S. , MCGEE, Lawrence, R. , VOUNATSOS, Filisaty , WIEDEMANN, Sean , WORTMAN, Sarah
IPC分类号： C07D211/76 , A61K31/45 , A61P35/00 , C07C309/04 , C07D498/04
摘要： The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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4.发明公开CIS-MORPHOLINONE AND OTHER COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 有权CIS-MORPHOLINON UND ANDERE VERBINDUNGEN ALS MDM2-INHIBITOREN ZUR BEHANDLUNG VON KREBS
公开(公告)号：EP2958902A1
公开(公告)日：2015-12-30
申请号：EP14708410.7
申请日：2014-02-18
申请人： Amgen Inc.
发明人： BARTBERGER, Michael, D. , BECK, Hilary, Plake , DEGRAFFENREID, Michael, R. , FOX, Brian, M. , GONZALEZ LOPEZ DE TURISO, Felix , JULIAN, Lisa, D. , KAYSER, Frank , MEDINA, Julio, C. , OLSON, Steven, H. , REW, Yosup , ROVETO, Philip, M. , SUN, Daqing , YAN, Xuelei
IPC分类号： C07D265/32 , C07D413/04 , C07D413/06 , C07D279/12 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P35/00
CPC分类号： C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D487/04
摘要： The present invention provides MDM2 inhibitor compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
摘要翻译： 本发明提供式（I）的MDM2抑制剂化合物或其药学上可接受的盐，其中变量如上所定义，哪些化合物可用作治疗剂，特别是用于治疗癌症。 本发明还涉及含有MDM2抑制剂的药物组合物。
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