公开(公告)号：EP2376455A1

公开(公告)日：2011-10-19

申请号：EP09793422.8

申请日：2009-12-16

申请人： Amgen Inc.

发明人： ALLEN, Jennifer R. ,  CHEN, Ning ,  FALSEY, James R. ,  FROHN, Michael ,  HARRINGTON, Paul ,  HU, Essa ,  KALLER, Matthew R. ,  KUNZ, Roxanne ,  MERCEDE, Stephanie J. ,  NGUYEN, Thomas T. ,  PICKRELL, Alexander J. ,  REICHELT, Andreas ,  RUMFELT, Shannon ,  RZASA, Robert M. ,  SHAM, Kelvin ,  SIEGMUND, Aaron C. ,  TEGLEY, Christopher M. ,  YAO, Guomin

IPC分类号： C07D213/74 ,  C07D213/84 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  A61K31/444 ,  A61P25/18

CPC分类号： C07D401/04 ,  C07D213/74 ,  C07D213/84 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14

摘要： Pyridine and pyrimidine compounds: (I); or a pharmaceutically acceptable salt thereof, wherein m, n, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , X
1 , X
2 , X
3 , X
4 , X
5 , X
6 , X
7 , X
8 , and Y are as defined in the specification; (II); or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , X
1 , X
2 , and ring A are as defined in the specification; and (III); or a pharmaceutically acceptable salt thereof, wherein m, n, y, R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
9 , X
1 , X
2 , and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

公开(公告)号：EP2569306A1

公开(公告)日：2013-03-20

申请号：EP11731557.2

申请日：2011-05-11

申请人： Amgen Inc.

发明人： ALLEN, Jennifer ,  FROHN, Michael ,  HARRINGTON, Paul ,  PICKRELL, Alexander ,  RZASA, Robert ,  SHAM, Kelvin ,  Harrington, Essa Hu

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4523 ,  A61K31/497 ,  A61K31/506 ,  A61P3/00 ,  A61P25/18

CPC分类号： C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Heteroaryloxycarbocyclyl compounds of formula (I), and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive -compulsive disorder, and the like. Formula (I)

摘要翻译： 式（I）的杂芳氧基碳环基化合物和含有它们的组合物，以及制备这些化合物的方法。 本文还提供了治疗可通过抑制PDE10治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相型障碍，强迫症等。 式（I）

公开(公告)号：EP2376455B1

公开(公告)日：2012-11-14

申请号：EP09793422.8

申请日：2009-12-16

申请人： Amgen Inc.

发明人： ALLEN, Jennifer R. ,  CHEN, Ning ,  FALSEY, James R. ,  FROHN, Michael ,  HARRINGTON, Paul ,  HU, Essa ,  KALLER, Matthew R. ,  KUNZ, Roxanne ,  MERCEDE, Stephanie J. ,  NGUYEN, Thomas T. ,  PICKRELL, Alexander J. ,  REICHELT, Andreas ,  RUMFELT, Shannon ,  RZASA, Robert M. ,  SHAM, Kelvin ,  SIEGMUND, Aaron C. ,  TEGLEY, Christopher M. ,  YAO, Guomin

IPC分类号： C07D213/74 ,  C07D213/84 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  A61K31/444 ,  A61P25/18

CPC分类号： C07D401/04 ,  C07D213/74 ,  C07D213/84 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14