公开(公告)号：EP1768986A2

公开(公告)日：2007-04-04

申请号：EP05763716.7

申请日：2005-06-29

申请人： Amgen Inc.

发明人： BUCHANAN, John L. ,  BUCKNER, William H. ,  BURKITT, Simon A. ,  DIMAURO, Erin F. ,  FARTHING, Christopher N. ,  FRENKEL, Alexander David ,  HARRISON, Martin J. ,  KAYSER, Frank ,  LIU, Jinqian ,  LIVELY, Sarah E. ,  MARSHALL, Teresa L. ,  MCGOWAN, David C. ,  SHARMA, Rajiv ,  SHUTTLEWORTH, Stephen Joseph ,  ZHU, Xiaotian

IPC分类号： C07D498/04 ,  A61K31/519

CPC分类号： C07D491/04 ,  C07D495/04

摘要： The present invention relates to furanopyrimidine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula (I), methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula (I). The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula (I).