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    HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9
    3.
    发明公开
    HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 审中-公开
    MENSCHLICHE抗原蛋白质蛋白质BINDUNG AN PROPROTEIN-KONVERTASE-SUBTILISIN / KEXIN TYP 9

    公开(公告)号：EP2968985A2

    公开(公告)日：2016-01-20

    申请号：EP14722880.3

    申请日：2014-03-14

    申请人： AMGEN, INC.

    发明人： MICHAELS, Mark, Leo ,  KETCHEM, Randal, R. ,  PIPER, Derek, E. ,  YAN, Wei ,  KING, Chadwick, Terence ,  HOWARD, Monique, LaRae

    IPC分类号： A61P3/06 ,  A61K39/395 ,  C07K16/40

    CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

    摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inhibiting PCSK9 binding to LDLR and having increased pH sensitivity, improved binding affinity and/or increased in vivos half life. In embodiments, the antigen binding proteins specifically bind PCSK9 and have increased pH sensitivity, improved binding affinity and/or increased in vivos half life. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind PCSK9 Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from hypercholesterolemia and related disorders or conditions.

    摘要翻译： 本发明提供与能够抑制PCSK9与LDLR结合并具有增加的pH敏感性，改善的结合亲和力和/或增加活体半衰期的抗原结合蛋白相关或衍生的组合物和方法。 在实施方案中，抗原结合蛋白特异性结合PCSK9并具有增加的pH敏感性，改善的结合亲和力和/或增加活体半衰期。 在一些实施方案中，抗原结合蛋白是完全人，人源化或嵌合抗体，此类抗体的结合片段和衍生物，以及特异性结合PCSK9的多肽。其他实施方案提供编码此类抗原结合蛋白的核酸及其片段和衍生物， 和多肽，包含此类多核苷酸的细胞，制备此类抗原结合蛋白的方法及其片段和衍生物，以及多肽，以及使用此类抗原结合蛋白，其片段及其衍生物和多肽的方法，包括治疗或诊断受试者的方法 来自高胆固醇血症和相关疾病或病症。