公开(公告)号：EP2260017A1

公开(公告)日：2010-12-15

申请号：EP09717135.9

申请日：2009-03-04

申请人： Amgen, Inc

发明人： BROWN, Sean, P. ,  DRANSFIELD, Paul, J. ,  HOUZE, Jonathan ,  KOHN, Todd, J. ,  LIU, Jiwen ,  MEDINA, Julio ,  PATTAROPONG, Vatee ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  YU, Ming ,  ZHU, Liusheng

IPC分类号： C07C59/72 ,  C07D213/64 ,  A61K31/192 ,  A61P3/10 ,  A61P9/00 ,  A61K31/435

CPC分类号： C07C59/72

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

公开(公告)号：EP2358656A2

公开(公告)日：2011-08-24

申请号：EP09741123.5

申请日：2009-10-13

申请人： Amgen, Inc

发明人： BROWN, Sean P. ,  DRANSFIELD, Paul ,  DU, Xiaohui ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, XianYun ,  LAI, SuJen ,  LI, An-Rong ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio C. ,  PATTAROPONG, Vatee ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  WANG, Zhongyu ,  YU, Ming ,  ZHU, Liusheng

IPC分类号： C07C62/34 ,  C07D249/00 ,  C07D277/00 ,  C07D311/00 ,  C07D231/00 ,  C07D271/00 ,  C07D221/00

CPC分类号： C07C62/34 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07D213/643 ,  C07D217/24 ,  C07D253/065 ,  C07D277/22 ,  C07D311/04 ,  C07D401/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

公开(公告)号：EP2358656B1

公开(公告)日：2014-01-01

申请号：EP09741123.5

申请日：2009-10-13

申请人： Amgen, Inc

发明人： BROWN, Sean P. ,  DRANSFIELD, Paul ,  DU, Xiaohui ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, XianYun ,  LAI, SuJen ,  LI, An-Rong ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio C. ,  PATTAROPONG, Vatee ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  WANG, Zhongyu ,  YU, Ming ,  ZHU, Liusheng

IPC分类号： C07C62/34 ,  C07D249/00 ,  C07D277/00 ,  C07D311/00 ,  C07D231/00 ,  C07D271/00 ,  C07D221/00

CPC分类号： C07C62/34 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07D213/643 ,  C07D217/24 ,  C07D253/065 ,  C07D277/22 ,  C07D311/04 ,  C07D401/12

公开(公告)号：EP2205548A1

公开(公告)日：2010-07-14

申请号：EP08837085.3

申请日：2008-10-03

申请人： Amgen, Inc

发明人： KIM, Yong-Jae ,  BROWN, Sean, P. ,  CAO, Qiong ,  DRANSFIELD, Paul, J. ,  DU, Xiaohui ,  HOUZE, Jonathan ,  JIAO, Xian Yun ,  KOHN, Todd, J. ,  LAI, Sujen ,  LI, An-Rong ,  LIN, Daniel ,  LUO, Jian ,  MEDINA, Julio, C. ,  REAGAN, Jeffrey, D. ,  PATTAROPONG, Vatee ,  SCHWARZ, Margrit ,  SHEN, Wang ,  SU, Yongli ,  SWAMINATH, Gayathri ,  VIMOLRATANA, Marc ,  WANG, Xiang ,  XIONG, Yumei ,  YANG, Li ,  YU, Ming ,  ZHANG, Jie ,  ZHU, Liusheng ,  FU, Zice ,  LIU, Jiwen ,  WANG, Yingcai

IPC分类号： C07C59/68 ,  C07C217/54 ,  C07C323/19 ,  C07D213/64 ,  A61K31/192 ,  A61K31/4415 ,  A61P3/10

CPC分类号： C07C323/62 ,  C07C59/68 ,  C07C59/72 ,  C07C217/54 ,  C07C217/62 ,  C07C317/22 ,  C07C323/19 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/74 ,  C07D213/64 ,  C07D309/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

摘要翻译： 本发明提供了可用于例如治疗受试者代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病如II型糖尿病中的使用方法。

公开(公告)号：EP2164828A2

公开(公告)日：2010-03-24

申请号：EP08743426.2

申请日：2008-05-01

申请人： Amgen Inc.

发明人： BROWN, Matthew ,  JOHNSON, Michael, G. ,  LI, An-Rong ,  LIU, Jiwen ,  LIVELY, Sarah, E. ,  MEDINA, Julio, C. ,  SHEN, Wang ,  WANG, Xuemei ,  WANG, Yingcai

IPC分类号： C07D209/08 ,  C07D209/34 ,  C07D209/42 ,  C07D209/48 ,  C07D215/38 ,  C07D231/56 ,  C07D235/08 ,  C07D277/82 ,  C07D471/04 ,  C07D215/227 ,  A61P11/06 ,  A61P37/08 ,  A61P17/06

CPC分类号： C07D209/08 ,  C07D209/10 ,  C07D209/34 ,  C07D209/42 ,  C07D209/48 ,  C07D213/68 ,  C07D213/76 ,  C07D215/38 ,  C07D231/56 ,  C07D235/08 ,  C07D235/22 ,  C07D277/82 ,  C07D405/12 ,  C07D471/04

摘要： The present invention is directed to compounds, compositions and methods useful for treating inflammatory and immune-related diseases and conditions. The compounds are modulators of prostaglandin D2 (PGD2) receptors including CRTH2 and DP receptors. The subject compounds are carboxylic acid derivatives of formulae (II) and (III): Formula (II), (III), wherein, X represents a divalent linkage selected from -O-, -S(O)k-., -CRaRb-, -C(O)-, -NR8- and -C(NR9)- Y represents a divalent linkage selected from a single bond, -S(O)kNR10-, -C(O)NR10-, (C1-C4)alkylene, hetero(C2-C4)alkyIene, -N(R11)C(O)NR10- -N(R11)S(O)kNR10-, -N(R11)CO2-, -NR11-, -O- and -S(O)k-. Z represents -CO2R12, -C(O)NR12R13 or heteroaryl. L represents a divalent linkage selected from a single bond, (C1-C6)alkylene, (C2-C6)alkenylene, (C2-C6)alkynylene and (C2-C4)heteroalkylene.

公开(公告)号：EP2164828B1

公开(公告)日：2013-03-27

申请号：EP08743426.2

申请日：2008-05-01

申请人： Amgen Inc.

发明人： BROWN, Matthew ,  JOHNSON, Michael, G. ,  LI, An-Rong ,  LIU, Jiwen ,  LIVELY, Sarah, E. ,  MEDINA, Julio, C. ,  SHEN, Wang ,  WANG, Xuemei ,  WANG, Yingcai

IPC分类号： C07D209/08 ,  C07D209/34 ,  C07D209/42 ,  C07D209/48 ,  C07D215/38 ,  C07D231/56 ,  C07D235/08 ,  C07D277/82 ,  C07D471/04 ,  C07D215/227 ,  A61P11/06 ,  A61P37/08 ,  A61P17/06

CPC分类号： C07D209/08 ,  C07D209/10 ,  C07D209/34 ,  C07D209/42 ,  C07D209/48 ,  C07D213/68 ,  C07D213/76 ,  C07D215/38 ,  C07D231/56 ,  C07D235/08 ,  C07D235/22 ,  C07D277/82 ,  C07D405/12 ,  C07D471/04

公开(公告)号：EP2064193A1

公开(公告)日：2009-06-03

申请号：EP07837816.3

申请日：2007-09-06

申请人： Amgen, Inc

发明人： BECK, Hilary ,  DRANSFIELD, Paul ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, XianYun ,  KOHN, Todd, J. ,  LAI, SuJen ,  LIU, Jinqian ,  LIU, Jiwen ,  MA, Zhihua ,  SCHMITT, Michael, J. ,  SHARMA, Rajiv ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  WANG, Zhongyu ,  MEDINA, Julio, C.

IPC分类号： C07D261/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  A61K31/42 ,  A61K31/422 ,  A61P3/10 ,  A61P3/04 ,  A61P9/00 ,  A61P9/10

CPC分类号： C07D261/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.