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1.发明授权HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS 有权人类抗NGF中和抗体作为选择性NGF途径抑制剂
公开(公告)号：EP1648509B8
公开(公告)日：2012-10-24
申请号：EP04778409.5
申请日：2004-07-15
申请人： Amgen Inc. , Medarex, Inc.
发明人： WILD, Kenneth, D., Jr. , TREANOR, James, J., S. , HUANG, Haichun , INOUE, Heather , ZHANG, Tie, J. , MARTIN, Frank
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/48 , G01N2800/2842
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
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2.发明授权
公开(公告)号：EP1648509B1
公开(公告)日：2012-09-12
申请号：EP04778409.5
申请日：2004-07-15
申请人： Amgen Inc. , Medarex, Inc.
发明人： WILD, Kenneth, D., Jr. , TREANOR, James, J., S. , HUANG, Haichun , INOUE, Heather , ZHANG, Tie, J. , MARTIN, Frank
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/48 , G01N2800/2842
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
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3.发明公开HUMAN ANTI-NGF NEUTRALIZING ANTIBODIES AS SELECTIVE NGF PATHWAY INHIBITORS 有权人文抗NGF NEUTRALISIERENDEANTIKÖRPERALS SELEKTIVE NGF，缝边
公开(公告)号：EP1648509A2
公开(公告)日：2006-04-26
申请号：EP04778409.5
申请日：2004-07-15
申请人： Amgen Inc.
发明人： WILD, Kenneth, D., Jr. , TREANOR, James, J., S. , HUANG, Haichun , INOUE, Heather , ZHANG, Tie, J. , MARTIN, Frank
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/48 , G01N2800/2842
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
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4.发明授权Peptides that modulate nerve growth factor (NGF) activity, their compositions and use 有权肽来调节神经生长因子（NGF）的活性，其组合物以及其用途
公开(公告)号：EP1545581B1
公开(公告)日：2012-10-24
申请号：EP03759405.8
申请日：2003-09-19
申请人： AMGEN INC.
CPC分类号： C07K16/22 , A61K38/00 , C07H21/04 , C07K7/08 , C07K14/001
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5.发明公开PEPTIDES AND RELATED MOLECULES THAT MODULATE NERVE GROWTH FACTOR ACTIVITY 有权肽来调节神经生长因子（NGF）的活性，其组合物以及其用途
公开(公告)号：EP1545581A1
公开(公告)日：2005-06-29
申请号：EP03759405.8
申请日：2003-09-19
申请人： AMGEN INC.
CPC分类号： C07K16/22 , A61K38/00 , C07H21/04 , C07K7/08 , C07K14/001
摘要： The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active polypeptides comprising peptides linked to one or more Fc domains are provided.
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