公开(公告)号：EP2807266B1

公开(公告)日：2020-01-15

申请号：EP13741489.2

申请日：2013-01-28

申请人： Amgen Inc.

发明人： XIONG, Yumei ,  ZHANG, Yi ,  SHENG, Jackie Zeqi ,  HAMBURGER, Agnes Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN,Gunasekaran ,  WALKER, Kenneth, W. ,  LEMON, Bryan

IPC分类号： C07K14/475 ,  A61K38/00 ,  A61K39/00 ,  C07K19/00

公开(公告)号：EP2807266A1

公开(公告)日：2014-12-03

申请号：EP13741489.2

申请日：2013-01-28

申请人： Amgen Inc.

发明人： XIONG, Yumei ,  ZHANG, Yi ,  SHENG, Jackie Zeqi ,  HAMBURGER, Agnes Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN,Gunasekaran ,  WALKER, Kenneth, W. ,  LEMON, Bryan

IPC分类号： C12P21/08 ,  A61K39/00

摘要： GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

摘要翻译： 提供GDF15多肽，包含GDF15的构建体及其突变体。 在各种实施方案中，GDF15多肽，包含GDF15的构建体及其突变体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，葡萄糖水平升高，胰​​岛素水平升高和糖尿病性肾病。

公开(公告)号：EP3027642B1

公开(公告)日：2020-08-19

申请号：EP14752711.3

申请日：2014-07-31

申请人： Amgen Inc.

发明人： XIONG, Yumei ,  ZHANG, Yi ,  SHENG, Jackie, Z. ,  HAMBURGER, Agnes, Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN, Gunasekaran ,  MOCK, Marissa ,  WALKER, Kenneth

IPC分类号： C07K14/475 ,  A61P13/12 ,  A61P3/00

公开(公告)号：EP3683228A3

公开(公告)日：2020-07-29

申请号：EP20151691.1

申请日：2013-01-28

申请人： Amgen Inc.

发明人： XIONG, YuMei ,  ZHANG, Yi ,  SHENG, Jackie Zeqi ,  HAMBURGER, Agnes Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN, Gunasekaran ,  WALKER, Kenneth W. ,  LEMON, Bryan

IPC分类号： C07K14/475 ,  A61K39/00

摘要： GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：EP3683228A2

公开(公告)日：2020-07-22

申请号：EP20151691.1

申请日：2013-01-28

申请人： Amgen Inc.

发明人： XIONG, YuMei ,  ZHANG, Yi ,  SHENG, Jackie Zeqi ,  HAMBURGER, Agnes Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN, Gunasekaran ,  WALKER, Kenneth W. ,  LEMON, Bryan

IPC分类号： C07K14/475 ,  A61K39/00

摘要： GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：EP3027642A1

公开(公告)日：2016-06-08

申请号：EP14752711.3

申请日：2014-07-31

申请人： AMGEN, INC.

发明人： XIONG, Yumei ,  ZHANG, Yi ,  SHENG, Jackie, Z. ,  HAMBURGER, Agnes, Eva ,  VENIANT-ELLISON, Murielle ,  SHIMAMOTO, Grant ,  MIN, Xiaoshan ,  WANG, Zhulun ,  TANG, Jie ,  KANNAN, Gunasekaran ,  MOCK, Marissa ,  WALKER, Kenneth

IPC分类号： C07K14/495 ,  C12N15/62

摘要： Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.