公开(公告)号：EP2077998A1

公开(公告)日：2009-07-15

申请号：EP07837737.1

申请日：2007-09-04

申请人： Amgen Inc. ,  Tasker, Andrew ,  Zhang, Dawei

发明人： TASKER, Andrew ,  ZHANG, Dawei ,  PETTUS, Liping, H. ,  RZASA, Robert, M. ,  SHAM, Kelvin, K.C. ,  XU, Shimin ,  CHAKRABARTI, Partha, Pratim

IPC分类号： C07D237/30 ,  C07D237/34 ,  C07D403/12 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04 ,  A61K31/501 ,  A61P29/00

CPC分类号： C07D403/12 ,  C07D237/30 ,  C07D237/34 ,  C07D403/10 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

公开(公告)号：EP2086973B1

公开(公告)日：2012-01-25

申请号：EP07839356.8

申请日：2007-10-05

申请人： Amgen Inc.,

发明人： ZHANG, Dawei ,  TASKER, Andrew ,  SHAM, Kelvin, K.C. ,  CHAKRABARTI, Partha, Pratim ,  FALSEY, Richard, James ,  HERBERICH, Bradley, J. ,  PETTUS, Liping, H. ,  RZASA, Robert, M.

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have general Formula (I), wherein A, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula (I).

公开(公告)号：EP2077998B1

公开(公告)日：2011-03-09

申请号：EP07837737.1

申请日：2007-09-04

申请人： Amgen Inc.

发明人： TASKER, Andrew ,  ZHANG, Dawei ,  PETTUS, Liping, H. ,  RZASA, Robert, M. ,  SHAM, Kelvin, K.C. ,  XU, Shimin ,  CHAKRABARTI, Partha, Pratim

IPC分类号： C07D237/30 ,  C07D237/34 ,  C07D403/12 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04 ,  A61K31/501 ,  A61P29/00

CPC分类号： C07D403/12 ,  C07D237/30 ,  C07D237/34 ,  C07D403/10 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

公开(公告)号：EP2086973A2

公开(公告)日：2009-08-12

申请号：EP07839356.8

申请日：2007-10-05

申请人： Amgen Inc.,

发明人： ZHANG, Dawei ,  TASKER, Andrew ,  SHAM, Kelvin, K.C. ,  CHAKRABARTI, Partha, Pratim ,  FALSEY, Richard, James ,  HERBERICH, Bradley, J. ,  PETTUS, Liping, H. ,  RZASA, Robert, M.

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have general Formula (I), wherein A, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula (I).