公开(公告)号：EP1786837A2

公开(公告)日：2007-05-23

申请号：EP05807469.1

申请日：2005-08-04

申请人： Amgen Inc.,

发明人： LI, Ji ,  SHEN, Wenyan ,  LU, Hsieng Sen ,  RICHARDS, William Gleason

IPC分类号： C07K16/18 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

公开(公告)号：EP1786837B1

公开(公告)日：2013-05-01

申请号：EP05807469.1

申请日：2005-08-04

申请人： Amgen Inc.,

发明人： LI, Ji ,  SHEN, Wenyan ,  LU, Hsieng Sen ,  RICHARDS, William Gleason

IPC分类号： C07K16/18 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92