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公开(公告)号：EP4327885A3
公开(公告)日：2024-06-05
申请号：EP23199712.3
申请日：2016-08-01
发明人： Raum, Tobias , Kufer, Peter , Rau, Doris , Anlahr, Jonas , Bluemel, Claudia , Hoffmann, Patrick , Nahrwold, Elisabeth , Bailis, Julie , Muenz, Markus , Brozy, Johannes , Friedrich, Matthias , Bogner, Pamela , Wolf, Andreas , Pompe, Cornelius , Rattel, Benno
IPC分类号： C07K16/28 , C07K16/30 , A61P35/00 , A61K39/395 , A61P35/04
CPC分类号： C07K16/30 , C07K2317/7320130101 , C07K2317/9420130101 , C07K16/2809 , C07K2317/3320130101 , C07K2317/3120130101 , C07K2317/9220130101 , C07K2317/62220130101 , A61P35/00 , A61P35/04 , A61P43/00
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：EP4327885A2
公开(公告)日：2024-02-28
申请号：EP23199712.3
申请日：2016-08-01
发明人： Raum, Tobias , Kufer, Peter , Rau, Doris , Anlahr, Jonas , Bluemel, Claudia , Hoffmann, Patrick , Nahrwold, Elisabeth , Bailis, Julie , Muenz, Markus , Brozy, Johannes , Friedrich, Matthias , Bogner, Pamela , Wolf, Andreas , Pompe, Cornelius , Rattel, Benno
IPC分类号： A61P43/00
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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3.发明公开Antibody neutralizers of human granulocyte macrophage colony stimulating factor 审中-公开Antikörperneutralisierer人粒细胞 - 巨噬细胞集落刺激因子的
公开(公告)号：EP2468774A3
公开(公告)日：2013-01-02
申请号：EP12159883.3
申请日：2006-04-18
发明人： Raum, Tobias , Hepp, Julia , Vieser, Eva , Petsch, Silke , Zeman, Steven , Wolf, Andreas , Bruckmaier, Sandra
IPC分类号： C07K16/24
CPC分类号： C07K16/243 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to a human monoclonal antibody or fragment thereof which specifically binds to and neutralizes primate GM-CSF.
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公开(公告)号：EP4206228A1
公开(公告)日：2023-07-05
申请号：EP22205186.4
申请日：2017-02-02
发明人： Raum, Tobias , Muenz, Markus , Brozy, Johannes , Kufer, Peter , Hoffmann, Patrick , Friedrich, Matthias , Rattel, Benno , Bogner, Pamela , Wolf, Andreas , Pompe, Cornelius
摘要： The present invention provides single chain polypeptides of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the polypeptide, a vector comprising this polynucleotide, host cells, expressing the polypeptide and a pharmaceutical composition comprising the same.
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