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    MIGALASTAT BOUND TO ALPHA GALACTOSIDASE A
    4.
    发明公开
    MIGALASTAT BOUND TO ALPHA GALACTOSIDASE A 审中-公开

    公开(公告)号：EP4062915A1

    公开(公告)日：2022-09-28

    申请号：EP22165647.3

    申请日：2018-05-30

    申请人： Amicus Therapeutics, Inc.

    发明人： CASTELLI, Jeff

    IPC分类号： A61K31/445 ,  A61P13/12 ,  A61K38/47

    摘要： Provided are methods for treatment of Fabry disease in a patient having renal impairment and/or elevated proteinuria. Certain methods comprise administering to the patient about 100 to about 150 mg free base equivalent of migalastat or salt thereof at a frequency of once every other day. Certain methods also provide for the stabilization of renal function, reducing left ventricular mass index, reducing plasma globotriaosylsphingosine and/or increasing α-galactosidase A activity in the patient.

    METHODS OF TREATING FABRY PATIENTS HAVING RENAL IMPAIRMENT
    8.
    发明公开
    METHODS OF TREATING FABRY PATIENTS HAVING RENAL IMPAIRMENT 审中-公开

    公开(公告)号：EP4062916A1

    公开(公告)日：2022-09-28

    申请号：EP22165669.7

    申请日：2018-05-30

    申请人： Amicus Therapeutics, Inc.

    发明人： CASTELLI, Jeff

    IPC分类号： A61K31/445 ,  A61P13/12

    摘要： Provided are methods for treatment of Fabry disease in a patient having renal impairment and/or elevated proteinuria. Certain methods comprise administering to the patient about 100 to about 150 mg free base equivalent of migalastat or salt thereof at a frequency of once every other day. Certain methods also provide for the stabilization of renal function, reducing left ventricular mass index, reducing plasma globotriaosylsphingosine and/or increasing a-galactosidase A activity in the patient.