公开(公告)号：EP2436688A1

公开(公告)日：2012-04-04

申请号：EP10780549.1

申请日：2010-05-25

申请人： AnGes MG, Inc.

发明人： GEMBA, Takefumi ,  TOMIOKA, Hideki ,  TAMURA, Nao ,  SATA, Ryoko ,  MAEDA, Akito ,  TENMA, Akiko ,  KANAMORI, Toshihide ,  SAITO, Yoshimi ,  KOMABA, Shintaro ,  MORISHITA, Ryuichi

IPC分类号： C07K7/08 ,  A61K38/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P17/02 ,  A61P31/04

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10

摘要： A novel polypeptide which has an excellent angiogenesis-inducing activity and an excellent antibacterial activity, and a novel angiogenesis-inducing agent which contains the polypeptide as an effective ingredient or a novel agent for treating a wound(s) which contains the polypeptide as an effective ingredient are disclosed. The polypeptide of the present invention is a polypeptide whose amino acid sequence is shown in any one of SEQ ID NOs:1 to 6, 8 and 10. The angiogenesis-inducing agent which contains the polypeptide of the present invention as an effective ingredient is useful for the prevention, amelioration or treatment of a disease such as a bums, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliteran.

公开(公告)号：EP2371840A9

公开(公告)日：2012-02-22

申请号：EP09829160.2

申请日：2009-11-27

申请人： AnGes MG, Inc.

发明人： GEMBA, Takefumi ,  TOMIOKA, Hideki ,  SATA, Ryoko ,  TAMURA, Nao ,  MAEDA, Akito ,  KANAMORI, Toshihide ,  SAITO, Yoshimi ,  KOMABA, Shintaro ,  MORISHITA, Ryuichi

IPC分类号： C07K7/08 ,  A61K38/00 ,  A61P9/00 ,  A61P9/10 ,  A61P17/00 ,  A61P17/02 ,  A61P31/04 ,  C07K14/435 ,  C07K14/515

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/515

摘要： Novel polypeptides which have an excellent angiogenesis-inducing activity and an excellent antibacterial activity and medical uses thereof are disclosed. The amino acid sequences of the novel polypeptides are shown in any one of SEQ ID NOs:1 to 6. These polypeptides have angiogenesis-inducing and antibacterial activities. Such polypeptides are useful for the prevention, amelioration or treatment of skin wounds caused by a cut wound, surgical wound, erosion, burn, decubitus,intractable wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease or arteriosclerosis obliteran, and for the prevention, amelioration or treatment of bacterial infection in such skin wounds, and the like.

摘要翻译： 公开了具有优异的血管生成诱导活性和优异的抗菌活性的新型多肽及其医学用途。 新多肽的氨基酸序列显示于SEQ ID NO：1至6中的任何一个中。这些多肽具有诱导血管发生和抗菌活性。 这样的多肽可用于预防，改善或治疗由切伤，手术伤口，侵蚀，烧伤，褥疮，顽固性伤口，皮肤溃疡，腿部溃疡，糖尿病性溃疡，闭塞性动脉疾病或闭塞性动脉硬化症引起的皮肤伤口， 在这种皮肤伤口中预防，改善或治疗细菌感染等。

公开(公告)号：EP2436688B1

公开(公告)日：2014-07-09

申请号：EP10780549.1

申请日：2010-05-25

申请人： AnGes MG, Inc.

发明人： GEMBA, Takefumi ,  TOMIOKA, Hideki ,  TAMURA, Nao ,  SATA, Ryoko ,  MAEDA, Akito ,  TENMA, Akiko ,  KANAMORI, Toshihide ,  SAITO, Yoshimi ,  KOMABA, Shintaro ,  MORISHITA, Ryuichi

IPC分类号： C07K7/08 ,  A61K38/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P17/02 ,  A61P31/04 ,  C07K14/47

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10

公开(公告)号：EP2371840B1

公开(公告)日：2014-04-16

申请号：EP09829160.2

申请日：2009-11-27

申请人： AnGes MG, Inc.

发明人： GEMBA, Takefumi ,  TOMIOKA, Hideki ,  SATA, Ryoko ,  TAMURA, Nao ,  MAEDA, Akito ,  KANAMORI, Toshihide ,  SAITO, Yoshimi ,  KOMABA, Shintaro ,  MORISHITA, Ryuichi

IPC分类号： C07K7/08 ,  A61K38/00 ,  A61P9/00 ,  A61P9/10 ,  A61P17/00 ,  A61P17/02 ,  A61P31/04 ,  C07K14/435 ,  C07K14/515

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/515

公开(公告)号：EP2371840A1

公开(公告)日：2011-10-05

申请号：EP09829160.2

申请日：2009-11-27

申请人： AnGes MG, Inc.

发明人： GEMBA, Takefumi ,  TOMIOKA, Hideki ,  SATA, Ryoko ,  TAMURA, Nao ,  MAEDA, Akito ,  KANAMORI, Toshihide ,  SAITO, Yoshimi ,  KOMABA, Shintaro ,  MORISHITA, Ryuichi

IPC分类号： C07K7/08 ,  A61K38/00 ,  A61P9/00 ,  A61P9/10 ,  A61P17/00 ,  A61P17/02 ,  A61P31/04 ,  C07K14/435 ,  C07K14/515

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/515

摘要： Novel polypeptides which have an excellent angiogenesis-inducing activity and an excellent antibacterial activity and medical uses thereof are disclosed. The amino acid sequences of the novel polypeptides are shown in any one of SEQ ID NOs:1 to 6. These polypeptides have angiogenesis-inducing and antibacterial activities. Such polypeptides are useful for the prevention, amelioration or treatment of skin wounds caused by a cut wound, surgical wound, erosion, bum, decubitus,intractable wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease or arteriosclerosis obliteran, and for the prevention, amelioration or treatment of bacterial infection in such skin wounds, and the like.

摘要翻译： 新颖多肽，其具有优异的血管生成诱导活性和优异的抗菌活性和医药用途它们的游离缺失光盘。 该新的多肽的氨基酸序列分别示于SEQ ID NO中的任一项：1至6。这些多肽具有血管生成诱导和抗菌活性。 搜索多肽是用于预防，改善或治疗由刀伤，手术创面，糜烂，烧伤，褥疮，顽固性伤口，皮肤溃疡，下肢溃疡，糖尿病性溃疡，闭塞性动脉疾病或动脉硬化obliteran引起皮肤伤口，以及用于 预防，改善或治疗细菌感染的寻求皮肤伤口，等等。