公开(公告)号：EP1671655A1

公开(公告)日：2006-06-21

申请号：EP04772726.8

申请日：2004-08-27

申请人： AnGes MG, Inc.

发明人： KUNUGIZA, Yasuo ,  TOMITA, Naruya ,  YOSHIKAWA, Hideki ,  TANIYAMA, Yoshiaki ,  TAMAI, Katsuto ,  MORISHITA, Ryuichi

IPC分类号： A61K48/00 ,  A61K38/16 ,  A61K31/7088 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61K9/08

CPC分类号： A61K9/0024 ,  A61K31/7088 ,  A61K48/0075

摘要： The present invention provides highly useful clinical methods for treating skin disorders, particularly intractable skin disorders. Specifically, the methods comprise injecting/subcutaneously introducing a 10 µg to 10 mg dose of a polynucleotide, such as a DNA, oligonucleotide, RNA, siRNA, and antisense, around a lesion associated with a skin disorder, such as a wound, cutaneous ulcer, or psoriasis, using a needleless syringe that injects a pharmaceutical liquid by using gas pressure or the elastic force of an elastic member to drive a piston.

摘要翻译： 本发明提供用于治疗皮肤病症，特别是顽固性皮肤病症的非常有用的临床方法。 具体地说，该方法包括将注射/皮下注射10μg至10mg剂量的多核苷酸，例如DNA，寡核苷酸，RNA，siRNA和反义，在与皮肤病例如伤口，皮肤溃疡相关的病变周围 或银屑病，使用无针注射器，其通过使用气体压力或弹性构件的弹力来驱动活塞而喷射药液。