公开(公告)号：EP4112605A1

公开(公告)日：2023-01-04

申请号：EP22745149.9

申请日：2022-01-21

申请人： Anhui Medical University

发明人： LIU, Xinhua ,  CHEN, Xing ,  SHI, Jingbo ,  LIU, Mingming ,  YAN, Yaoyao ,  ZHANG, Zhaoyan ,  ZHANG, Famin

IPC分类号： C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D403/12 ,  A61P29/00 ,  A61P37/00 ,  A61P19/02 ,  A61P1/18 ,  A61P13/12 ,  A61P11/00 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/505 ,  A61K31/541

摘要： The present disclosure discloses a pyrimidine-2,4-diamine compound and a preparation method and application thereof, relating to the technical field of medicinal chemistry. The pyrimidine-2,4-diamine compound of the present disclosure can be used in the research of biological or pharmacological phenomena and cathepsin C-involved signal pathway transduction and the evaluation of novel cathepsin C inhibitors. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-cathepsin C activity in vitro and in vivo and proved to have strong inhibitory activity on cathepsin C. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-NSP activity in vivo and proved to have strong inhibitory activity on NSP. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-inflammatory activity in vivo and proved to have an effective therapeutic effect on inflammatory disease models. Meanwhile, the pyrimidine-2,4-diamine compound shows low toxicity and exhibits good application prospect.