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公开(公告)号：EP2838531B1
公开(公告)日：2016-09-21
申请号：EP13777764.5
申请日：2013-04-03
IPC分类号： A61K31/522 , A61P35/00 , C07D401/14 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/06 , C07D409/06 , C07D473/32
CPC分类号： C07D209/34 , A61K31/522 , A61K38/45 , C07D209/00 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/06 , C07D409/06 , C07D473/32
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公开(公告)号：EP3624804A1
公开(公告)日：2020-03-25
申请号：EP18801840.2
申请日：2018-05-15
发明人： CHERN, Ji-Wang , YU, Chao-Wu , LIU, Jia-Rong , HO, Yi-Hsun , WU, Chia-Yu , HUANG, Chan-Hui , HUNG, Pei-Yun
IPC分类号： A61K31/517 , C07D239/88 , C07D239/91 , C07D239/96
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公开(公告)号：EP2838538B1
公开(公告)日：2017-03-15
申请号：EP13778039.1
申请日：2013-04-02
发明人： CHERN, Ji-Wang , LAI, Shin-Yu , CHANG, Pei-Teh
IPC分类号： C07D473/32 , A61K31/522 , A61P31/22
CPC分类号： C07D209/34 , A61K31/522 , A61K38/45 , C07D209/00 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/06 , C07D409/06 , C07D473/32
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公开(公告)号：EP2836484B1
公开(公告)日：2017-06-14
申请号：EP13775887.6
申请日：2013-04-02
发明人： CHERN, Ji-Wang , YU, Chao-Wu , CHANG, Pei-Teh
IPC分类号： C07D403/06 , C07D239/91 , A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , C07D239/91 , C07D403/06
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公开(公告)号：EP2838538A1
公开(公告)日：2015-02-25
申请号：EP13778039.1
申请日：2013-04-02
发明人： CHERN, Ji-Wang , LAI, Shin-Yu , CHANG, Pei-Teh
IPC分类号： A61K31/522
CPC分类号： C07D209/34 , A61K31/522 , A61K38/45 , C07D209/00 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/06 , C07D409/06 , C07D473/32
摘要： Cydopropanecarboxylate esters of purine analogues, method of making and using the same for treating herpes virus infections and tumors are disclosed. In an embodiment of the invention, the compound of the invention may be used for treating cancer A cancer patient may be first administered a vector, such as an adenovector, comprising a DNA insert encoding HSV thymidme kinase, said vector expressing HSV thymidine kinase in the tumor cells of the subject, followed by administration of the compound of the invention. In another aspect the invention relates to use of a compound or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof as aforementioned in the manufacture of a medicament for treating herpes virus infection. The medicament may be for treating herpes simplex virus infection, herpes zoster infection, or cytomegalovirus infection.
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公开(公告)号：EP2838531A1
公开(公告)日：2015-02-25
申请号：EP13777764.5
申请日：2013-04-03
IPC分类号： A61K31/404
CPC分类号： C07D209/34 , A61K31/522 , A61K38/45 , C07D209/00 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/06 , C07D409/06 , C07D473/32
摘要： A novel class of indoline-2-one derivatives are disclosed. These compounds are protein kinase inhibitors which are useful for treating hyperproliferative diseases such as cancer. In one embodiment of the invention, the cancer is at least one selected from the group consisting of lung cancer, colorectal cancer, liver cancer and acute myelomonocytic leukemia.
摘要翻译： 公开了一类新的二氢吲哚-2-酮衍生物。 这些化合物是蛋白激酶抑制剂，其可用于治疗过度增殖性疾病如癌症。 在本发明的一个实施方案中，癌症是选自肺癌，结直肠癌，肝癌和急性骨髓单核细胞性白血病中的至少一种。
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公开(公告)号：EP2836484A1
公开(公告)日：2015-02-18
申请号：EP13775887.6
申请日：2013-04-02
发明人： CHERN, Ji-Wang , YU, Chao-Wu , CHANG, Pei-Teh
IPC分类号： C07D239/90
CPC分类号： A61K31/517 , C07D239/91 , C07D403/06
摘要： Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit are also disclosed. In an embodiment of the invention, the compound is (2E)-3-(2-ethyl-6-fluoro-3,4-dihydro-4-oxo-3-phenethylquina20lin-7-yl)-N-hydroxyacrylamide, or a salt thereof. In another embodiment of the invention, the compound is (2E)-3-(2-ethyl-7-f1uoro-3,4-dihydro-4-oxo-3-phenethylquinazolin-6-yl)-N-hydroxyacrylamide, (2E)-3-(7-chloro-2-ethyl-3,4-dihydro-4-oxo-3-phenethylquinazolin-6-yl)-N-hydroxyacrylamide, or a salt thereof. In another aspect the invention relates to a composition comprising a therapeutically effective amount of a compound as aforementioned, or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof, and a pharmaceutically acceptable carrier or vehicle.
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