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公开(公告)号：EP1196420B1
公开(公告)日：2003-03-19
申请号：EP00945949.6
申请日：2000-07-24
申请人： Antibioticos S.p.A.
IPC分类号： C07D501/04
CPC分类号： C07D501/00
摘要： A process for the preparation of Cefuroxime acid or of a corresponding pharmaceutically acceptable salt or ester, by reaction of a 3-hydroxymethylceph-3-em precursor thereof with activated isocyanates in carbonic acid esters.
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公开(公告)号：EP1425285A1
公开(公告)日：2004-06-09
申请号：EP02774564.5
申请日：2002-09-04
申请人： Antibioticos S.p.A.
IPC分类号： C07D501/00
CPC分类号： C07D501/00
摘要： The present invention relates to a process for the preparation of crystalline cefuroxime axetil with high purity lecel and optimal diastereomeric ratio. Said process, which comprises the use of a dimethyl carbonate for isolating crystallizing cefuroxime axetil, is particularly suitable for implementing on an industrial scale.
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公开(公告)号：EP1423395A1
公开(公告)日：2004-06-02
申请号：EP02794534.4
申请日：2002-08-01
申请人： Antibioticos S.p.A.
IPC分类号： C07D501/34
CPC分类号： C07D501/00
摘要： A process for the preparation of highly pure cefuroxime axetil is herein described. The process makes use of a treatment, which allows removing an impurity present in the reagent l-acetoxyethyl bromide and responsible for the formation of cefuroxime dimeric derivatives. The removal of said impurity makes it easier to recover crystalline cefuroxime axetil and allows obtaining an exceptional-quality product.
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公开(公告)号：EP1196420A1
公开(公告)日：2002-04-17
申请号：EP00945949.6
申请日：2000-07-24
申请人： Antibioticos S.p.A.
IPC分类号： C07D501/04
CPC分类号： C07D501/00
摘要： A process for the preparation of Cefuroxime acid or of a corresponding pharmaceutically acceptable salt or ester, by reaction of a 3-hydroxymethylceph-3-em precursor thereof with activated isocyanates in carbonic acid esters.
摘要翻译： 通过其3-羟甲基头孢-3-烯前体与活化的异氰酸酯在碳酸酯中反应制备头孢呋辛酸或相应的药学上可接受的盐或酯的方法。
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