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1.发明授权
公开(公告)号：EP2866824B1
公开(公告)日：2016-08-10
申请号：EP13730877.1
申请日：2013-06-19
CPC分类号： C07K7/64 , A61K38/191
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2.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A CYCLIC PEPTIDE OF FORMULA X1 -GQRETPEGAEAKPWY-X2 AND USE FOR EXTRACORPOREAL LUNG TREATMENT 审中-公开与环状肽FORMULA X1-X2 GQRETPEGAEAKPWY AND USE药物组合物用于治疗肺癌的张福亭
公开(公告)号：EP2988769A1
公开(公告)日：2016-03-02
申请号：EP14721803.6
申请日：2014-04-18
发明人： FISCHER, Hendrik , PIETSCHMANN, Helmut , TZOTZOS, Susan Jane , FISCHER, Bernhard , LUCAS, Rudolf
摘要： A method of conditioning/improving lung functions extracorporeally by treatment of a lung ex vivo with a cyclized compound of the amino acid sequence of formula X1-GQRETPEGAEAKPWY-X2 I wherein X1 comprises an amino acid (sequence) with 1 to 4 members, comprising natural or unnatural amino acids, and X2 comprises one amino acid, selected from natural amino acids; and a pharmaceutical composition, comprising a peptide of formula I as defined in any one of claims 1 to 7, in a form, which is appropriate for spraying to obtain an aerosol for inhalation, or which is appropriate for the preparation of a spray to obtain an aerosol upon spraying, which is appropriate for inhalation.
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公开(公告)号：EP2219663B9
公开(公告)日：2013-01-23
申请号：EP08858971.8
申请日：2008-12-12
发明人： FISCHER, Bernhard , LUCAS, Rudolf
IPC分类号： A61K38/19 , C07K14/525
CPC分类号： C07K14/525 , A61K38/00 , C07K2319/00
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4.发明公开VERFAHREN ZUR VERMEIDUNG UND ZUR BEHANDLUNG EINER HYPERPERMEABILITÄT 有权VERFAHREN ZUR VERMEIDUNG UND ZUR BEHANDLUNG EINERHYPERPERMEABILITÄT
公开(公告)号：EP2403519A1
公开(公告)日：2012-01-11
申请号：EP10709949.1
申请日：2010-03-05
发明人： FISCHER, Bernhard , LUCAS, Rudolf
IPC分类号： A61K38/19
CPC分类号： C07K7/64 , A61K38/12 , A61K38/191
摘要： The invention relates to a peptide consisting of 7-17 adjoining amino acids and comprising the hexamer TX
1 EX
2 X
3 E, where X
1 , X
2 and X
3 can each be a natural or non-natural amino acid, wherein the peptide has no TNF receptor binding activity and is cyclized, for preventing and treating the hyperpermeability of epithelial cells and endothelial cells.摘要翻译： 描述了一种肽，其由7-17个相邻氨基酸组成并且包含六聚体TX EX XE，其中X，X和X可以是任何天然或非天然氨基酸，其中所述肽不具有TNF受体结合活性，并且是 环化，用于预防和治疗上皮细胞和内皮细胞的高渗透性。
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公开(公告)号：EP2217619A1
公开(公告)日：2010-08-18
申请号：EP08859641.6
申请日：2008-12-12
发明人： FISCHER, Bernhard , LUCAS, Rudolf
IPC分类号： C07K14/525 , A61K38/19
CPC分类号： A61K38/191 , C07K14/525
摘要： The invention relates to a protein which is selected from the amino acid sequence of the region valine Val(91) to glycine Gly(121) of the mature, human tumor necrosis factor, or a part thereof, provided that the protein comprises at least the amino acid sequence of the region lysine Lys(98) to glutamic acid Glu(116), the cysteine Cys(101) being replaced by a glycine and an amide bond being formed between the amino group of the side chain of the lysine Lys(98) and the carboxyl group of the side chain of the glutamic acid Glu(116). The protein activates epithelial ion channels and improves the pulmonary function and can be used to produce drugs for the treatment of diseases that are associated with the pulmonary function, such as oedema.
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6.发明授权ZUSAMMENSETZUNG UMFASSEND EIN PEPTID UND EIN HEMMSTOFF DER VIRALEN NEURAMINIDASE 有权组合物，含有肽和病毒神经氨酸抑制剂
公开(公告)号：EP2640410B1
公开(公告)日：2014-10-29
申请号：EP11785277.2
申请日：2011-11-15
CPC分类号： C07K7/64 , A61K38/191 , A61K45/06 , A61K2300/00
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7.发明公开ZUSAMMENSETZUNG UMFASSEND EIN PEPTID UND EIN HEMMSTOFF DER VIRALEN NEURAMINIDASE 有权组合物，含有肽和病毒神经氨酸抑制剂
公开(公告)号：EP2640410A1
公开(公告)日：2013-09-25
申请号：EP11785277.2
申请日：2011-11-15
CPC分类号： C07K7/64 , A61K38/191 , A61K45/06 , A61K2300/00
摘要： Described is a composition comprising - a peptide which consists of 7-17 adjacent amino acids and comprises the hexamer TX
1 EX
2 X
3 E, where X
1 , X
2 and X
3 can be any natural or non-natural amino acid, and the peptide is cyclized and does not exhibit TNF receptor binding activity, and - an inhibitor of viral neuraminidase.-
公开(公告)号：EP2988769B1
公开(公告)日：2020-05-27
申请号：EP14721803.6
申请日：2014-04-18
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9.发明公开LYOPHILISAT ENTHALTEND EIN ZYKLISCHES PEPTID DER FORMEL X1 -GQRETPEGAEAKPWY-X2 审中-公开冻干物含有式X1-X2的环肽-GQRETPEGAEAKPWY
公开(公告)号：EP2988768A1
公开(公告)日：2016-03-02
申请号：EP14718432.9
申请日：2014-04-18
发明人： FISCHER, Bernhard , LUCAS, Rudolf
CPC分类号： C07K7/64 , A61K9/0073 , A61K38/12 , A61K38/191
摘要： A cyclic peptide of forumula (I) X
1 -GQRETPEGAEAKPWY-X
2 , wherein X
1 comprises an amino acid (sequence) with 1 to 4 members, including natural or unnatural amino acids, and X2 comprises a natural amino acid, and wherein X
1 contains the N-terminal amino acid on the left in position 1, and X
2 contains the C-terminal amino acid in the last position on the right, in the form of a lyophilisate without additives and/or stabilizers and the use thereof.-
10.发明公开
公开(公告)号：EP2866824A1
公开(公告)日：2015-05-06
申请号：EP13730877.1
申请日：2013-06-19
CPC分类号： C07K7/64 , A61K38/191
摘要： What is described is a peptide which consists of 7‑20, especially 7‑17, adjacent amino acids and comprises the hexamer TX
1 EX
2 X
3 E where X
1 , X
2 and X
3 may be any natural or unnatural amino acid, where the peptide does not have any TNF receptor binding activity and is cyclized, for use for the treatment and avoidance of the pulmonary form of altitude sickness.摘要翻译： 肽包含7-17个连续氨基酸和六聚体，其中所述肽不包含，肿瘤坏死因子（TNF）受体结合活性和环化，是新的。 肽包含7-17个连续氨基酸和式（TX1EX2X3E），其中所述肽不包含，肿瘤坏死因子（TNF）受体结合活性和环化，是新的六聚体。 X1，X2，X3：天然或非天然的氨基酸。 N.B：T和E的没有定义。 一个独立的claimsoft包含用于组合物包含所述肽，所有这些在施用给人类，和载体组合物配制。 活动：没有给出。 作用机理：没有给出。
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