公开(公告)号：EP2334315A2

公开(公告)日：2011-06-22

申请号：EP09812187.4

申请日：2009-09-02

申请人： Arbor Vita Corporation ,  Nono, Inc.

发明人： BELMARES, Michael P. ,  GARMAN, J. David ,  LU, Peter S. ,  SALTER, Michael W. ,  TYMIANSKI, Michael

IPC分类号： A61K38/00

CPC分类号： C07K7/08 ,  A61K38/08 ,  A61K38/10 ,  C07K7/06

摘要： The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat-NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS.