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公开(公告)号：EP1722759A2
公开(公告)日：2006-11-22
申请号：EP05717745.3
申请日：2005-02-18
发明人： DYER, Ann, Margaret, Archimedes Development Ltd. , PASTOR, Patricia, Archimedes Development Ltd. , ILLUM, Lisbeth
IPC分类号： A61K9/00
CPC分类号： A61K47/36 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K31/485 , A61K38/23 , A61K47/26
摘要： The invention provides a composition comprising (i) chitosan, a sait or derivative thereof or a sait of a derivative thereof, (ii) a polyol-phosphate or sugar-phosphate salt, (iii) a plasticizer, and (iv) a therapeutic agent. Typically, the composition is a solution or suspension at ambient temperature but forms a gel at physiological temperatures.
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公开(公告)号：EP1622601A1
公开(公告)日：2006-02-08
申请号：EP04732650.9
申请日：2004-05-13
IPC分类号： A61K31/19 , A61K31/722 , A61K9/00
CPC分类号： A61K9/4808 , A61K9/1617 , A61K9/1652 , A61K9/205 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/722 , A61K38/00
摘要： The present invention provides a solid composition for oral administration comprising: (i) a drug compound; (ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of chitosan; and (iii) an organic acid. Preferably the drug compound is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide. The compositions of the invention provide enhance absorption of the drug compound.
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公开(公告)号：EP1035833B1
公开(公告)日：2005-08-31
申请号：EP98955814.3
申请日：1998-11-27
CPC分类号： A61K9/0043 , A61K47/61
摘要： There is provided a composition for the nasal delivery of a drug suitable for the treatment of erectil dysfunction to a mammal wherein the composition is adapted to provide an initial rise in plasma level followed by a sustained plasma level of the drug.
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4.发明授权NASAL DELIVERY COMPOSITION COMPRISING THE METHANE SULPHONATE SALT OF MORPHINE AND CHITOSAN 有权成分用于鼻VERABREICHERUNG吗啡甲磺酸和壳聚糖
公开(公告)号：EP1224188B1
公开(公告)日：2007-01-17
申请号：EP00969679.0
申请日：2000-10-19
发明人： ILLUM, Lisbeth , WATTS, Peter , SMITH, Alan , LAFFERTY, Ian
IPC分类号： C07D489/04 , A61K31/485 , A61P25/04
CPC分类号： C07D489/04
摘要： The methane sulphonate salt of morphine and compositions thereof are described. Also described is a composition adapted for nasal delivery comprising a methane sulphonate salt of an opioid analgesic.
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5.发明授权
公开(公告)号：EP1722759B1
公开(公告)日：2011-03-09
申请号：EP05717745.3
申请日：2005-02-18
发明人： DYER, Ann, Margaret, Archimedes Development Ltd. , PASTOR, Patricia, Archimedes Development Ltd. , ILLUM, Lisbeth
IPC分类号： A61K9/00
CPC分类号： A61K47/36 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K31/485 , A61K38/23 , A61K47/26
摘要： The invention provides a composition comprising (i) chitosan, a sait or derivative thereof or a sait of a derivative thereof, (ii) a polyol-phosphate or sugar-phosphate salt, (iii) a plasticizer, and (iv) a therapeutic agent. Typically, the composition is a solution or suspension at ambient temperature but forms a gel at physiological temperatures.
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公开(公告)号：EP1622601B1
公开(公告)日：2009-02-11
申请号：EP04732650.9
申请日：2004-05-13
IPC分类号： A61K31/19 , A61K31/722 , A61K9/00
CPC分类号： A61K9/4808 , A61K9/1617 , A61K9/1652 , A61K9/205 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/722 , A61K38/00
摘要： The present invention provides a solid composition for oral administration comprising: (i) a drug compound; (ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of chitosan; and (iii) an organic acid. Preferably the drug compound is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide. The compositions of the invention provide enhance absorption of the drug compound.
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