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1.发明公开Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto 审中-公开三取代的芳基和杂芳基衍生物作为代谢的调节剂，以及预防和治疗相关病症的
公开(公告)号：EP1923390A1
公开(公告)日：2008-05-21
申请号：EP07023527.0
申请日：2004-07-09
发明人： Jones, Robert M. , Semple, Graeme , Xiong, Yifeng , Shin, Young-Jun , Ren, Albert S. , Calderon, Imelda , Choi, Jin Sun Karoline , Fioravanti, Beatriz , Lehmann, Juerg , Bruce, Marc A.
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D239/52 , A61K31/506 , A61K31/5377 , A61K31/505 , A61P3/10
CPC分类号： C07D239/52 , C07D239/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to certain trisubstituted aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.
Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.摘要翻译： 本发明涉及式（I）的某些三取代的芳基和杂芳基衍生物没有被代谢的调节剂。 因此，本发明的化合物可用于代谢紊乱及其并发症，：如，糖尿病和肥胖的预防或治疗是有用的。
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公开(公告)号：EP2292620A3
公开(公告)日：2011-06-22
申请号：EP10009692.4
申请日：2004-07-13
发明人： Jones, Robert, M. , Semple, Graeme , Xiong, Yifeng , Shin, Young-Jun , Ren, Albert, S. , Calderon, Imelda , Fioravanti, Beatriz , Choi, Jin, Sun, Karoline , Sage, Carleton, R.
IPC分类号： C07D487/04 , C07D473/00 , C07D498/04 , C07D471/04 , C07D215/22 , A61K31/519 , A61K31/52 , A61K31/4375 , A61K31/47 , A61P3/00 , A61P3/10
CPC分类号： C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.
Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.-
3.发明公开Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto 审中-公开稠芳基和杂衍生物作为代谢的调节剂，以及预防和治疗相关病症的
公开(公告)号：EP2287166A2
公开(公告)日：2011-02-23
申请号：EP10008982.0
申请日：2004-07-13
发明人： Jones, Robert M. , Semple, Graeme , Xiong, Yifeng , Shin, Young-Jun , Ren, Albert S. , Calderon, Imelda , Fioravanti, Beatriz , Choi, Jin Sun Karoline , Sage, Carleton R.
IPC分类号： C07D487/04 , C07D473/00 , C07D498/04 , C07D471/04 , C07D215/22 , A61K31/519 , A61K31/52 , A61K31/4375 , A61K31/47 , A61P3/00 , A61P3/10
CPC分类号： C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.
Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.-
4.发明公开Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto 审中-公开作为代谢调节剂的稠合芳基和杂芳基衍生物以及预防和治疗与其有关的病症
公开(公告)号：EP2287165A2
公开(公告)日：2011-02-23
申请号：EP10008981.2
申请日：2004-07-13
发明人： Jones, Robert M. , Semple, Graeme , Xiong, Yifeng , Shin, Young-Jun , Ren, Albert S. , Calderon, Imelda , Fioravanti, Beatriz , Choi, Jin Sun Karoline , Sage, Carleton R.
IPC分类号： C07D487/04 , C07D473/00 , C07D498/04 , C07D471/04 , C07D215/22 , A61K31/519 , A61K31/52 , A61K31/4375 , A61K31/47 , A61P3/00 , A61P3/10
CPC分类号： C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.
Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.摘要翻译： 本发明涉及作为代谢调节剂的式（I）的某些稠合芳基和杂芳基衍生物。 因此，本发明化合物可用于预防或治疗代谢紊乱及其并发症，例如糖尿病和肥胖症。
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5.发明公开Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto 审中-公开稠芳基和杂衍生物作为代谢的调节剂，以及预防和治疗相关病症的
公开(公告)号：EP2287165A3
公开(公告)日：2011-06-22
申请号：EP10008981.2
申请日：2004-07-13
发明人： Jones, Robert M. , Semple, Graeme , Xiong, Yifeng , Shin, Young-Jun , Ren, Albert S. , Calderon, Imelda , Fioravanti, Beatriz , Choi, Jin Sun Karoline , Sage, Carleton R.
IPC分类号： C07D487/04 , C07D473/00 , C07D498/04 , C07D471/04 , C07D215/22 , A61K31/519 , A61K31/52 , A61K31/4375 , A61K31/47 , A61P3/00 , A61P3/10
CPC分类号： C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.
Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.摘要翻译： 本发明涉及式（I）的某些稠合的芳基和杂芳基衍生物没有被代谢的调节剂。 因此，本发明的化合物可用于代谢紊乱及其并发症，：如，糖尿病和肥胖的预防或治疗是有用的。
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6.发明公开Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto 审中-公开作为代谢调节剂的稠合 - 芳基和杂芳基衍生物以及预防和治疗与其相关的病症
公开(公告)号：EP2292620A2
公开(公告)日：2011-03-09
申请号：EP10009692.4
申请日：2004-07-13
发明人： Jones, Robert, M. , Semple, Graeme , Xiong, Yifeng , Shin, Young-Jun , Ren, Albert, S. , Calderon, Imelda , Fioravanti, Beatriz , Choi, Jin, Sun, Karoline , Sage, Carleton, R.
IPC分类号： C07D487/04 , C07D473/00 , C07D498/04 , C07D471/04 , C07D215/22 , A61K31/519 , A61K31/52 , A61K31/4375 , A61K31/47 , A61P3/00 , A61P3/10
CPC分类号： C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.
Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.摘要翻译： 本发明涉及作为代谢调节剂的式（I）的某些稠合芳基和杂芳基衍生物。 因此，本发明化合物可用于预防或治疗代谢紊乱及其并发症，例如糖尿病和肥胖症。
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公开(公告)号：EP2287166A3
公开(公告)日：2011-06-22
申请号：EP10008982.0
申请日：2004-07-13
发明人： Jones, Robert M. , Semple, Graeme , Xiong, Yifeng , Shin, Young-Jun , Ren, Albert S. , Calderon, Imelda , Fioravanti, Beatriz , Choi, Jin Sun Karoline , Sage, Carleton R.
IPC分类号： C07D487/04 , C07D473/00 , C07D498/04 , C07D471/04 , C07D215/22 , A61K31/519 , A61K31/52 , A61K31/4375 , A61K31/47 , A61P3/00 , A61P3/10
CPC分类号： C07D215/233 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.
Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.-
8.发明公开1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia 审中-公开1,2,3-三取代的芳基和杂芳基衍生物作为代谢的调节剂和糖尿病和高血糖相关的疾病的预防和治疗
公开(公告)号：EP1927594A1
公开(公告)日：2008-06-04
申请号：EP07019362.8
申请日：2004-01-14
发明人： Jones, Robert M , Semple, Graeme , Fioravanti, Beatriz , Pereira, Guilherme , Calderon, Imelda , Uy, Jane , Duvvuri, Kameshwari , Choi, Jin Sun Karoline , Xiong, Yifeng , Dave, Vibha , Azimioara, Mihai D.
IPC分类号： C07D401/14 , C07D401/04 , C07D413/14 , C07D403/14 , C07D405/14 , C07D417/14 , A61K31/506 , A61K31/513 , A61P3/10
CPC分类号： C07D213/68 , C07D213/79 , C07D239/34 , C07D239/50 , C07D295/096 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D411/14 , C07D413/14 , C07D417/14 , C07D419/14
摘要： The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Fomula (1a) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.
摘要翻译： 本发明涉及Fomula（1a）的某些1,2,3-三取代的芳基和杂芳基衍生物没有被代谢的调节剂。 因此，本发明的化合物可用于代谢紊乱及其并发症，：如，糖尿病和肥胖的预防或治疗是有用的。
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