公开(公告)号：EP2951592A1

公开(公告)日：2015-12-09

申请号：EP14745938.2

申请日：2014-01-30

申请人： Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University

发明人： ANDERSON, Karen ,  LABAER, Joshua ,  WALLSTROM, Garrick ,  CRAMER, Daniel

IPC分类号： G01N33/574

CPC分类号： G01N33/57488 ,  G01N33/57449 ,  G01N2333/471 ,  G01N2333/4748 ,  G01N2333/5756 ,  G01N2333/90666 ,  G01N2333/914 ,  G01N2800/7028

摘要： Methods for identifying antigens as potential biomarkers for the early detection of ovarian cancer, as well as kits for utilizing said antigens as biomarkers and in personalized medicine/therapeutics assessment. Protein microarrays displaying full-length candidate antigens were developed and sequentially screening to select candidate autoantibody biomarkers to limit the false discovery rate inherent to large-scale proteomic screening.

摘要翻译： 将抗原识别为用于早期检测卵巢癌的潜在生物标志物的方法，以及用于利用所述抗原作为生物标志物和个性化药物/治疗学评估的试剂盒。 开发显示全长候选抗原的蛋白质微阵列，并依次筛选选择候选自身抗体生物标志物，以限制大规模蛋白质组学筛选固有的假发现率。