公开(公告)号：EP1684694A2

公开(公告)日：2006-08-02

申请号：EP04811755.0

申请日：2004-11-19

申请人： Array Biopharma, Inc.

发明人： MITCHELL, Ian, S. ,  SPENCER, Keith, L. ,  STENGEL, Peter ,  HAN, Yongxin ,  KALLAN, Nicholas, C. ,  MUNSON, Mark ,  VIGERS, Guy, P., A. ,  BLAKE, James ,  PISCOPIO, Anthony ,  JOSEY, John ,  MILLER, Scott ,  XIAO, Dengming ,  XU, Riu ,  RAO, Chang ,  WANG, Bin ,  BERNACKI, April, L.

IPC分类号： A61K6/00

CPC分类号： C07D239/94 ,  B41M3/008 ,  B44F1/10 ,  C07D231/56 ,  C07D237/28 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/04 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  G09F13/16 ,  Y10T428/24802 ,  Y10T428/24851 ,  Y10T428/25 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31786 ,  Y10T428/31855

摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.