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公开(公告)号:EP2681215B1
公开(公告)日:2015-04-22
申请号:EP12709429.0
申请日:2012-02-28
发明人: BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark , BOYD, Steven
IPC分类号: C07D471/04 , A61K31/519 , A61P35/00
CPC分类号: C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
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公开(公告)号:EP2681215A1
公开(公告)日:2014-01-08
申请号:EP12709429.0
申请日:2012-02-28
发明人: BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark
IPC分类号: C07D471/04 , A61K31/519 , A61P35/00
CPC分类号: C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
摘要: Compounds having the formula I wherein Z, Z1 Z2 Z, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
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