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1.发明授权CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS 有权环磷酰胺[D] - 吡咯烷酮AKT-PROTEINKINASEHEMMER
公开(公告)号：EP2049500B1
公开(公告)日：2011-09-07
申请号：EP07799329.3
申请日：2007-07-05
发明人： MITCHELL, Ian S. , BLAKE, James F. , XU, Rui , KALLAN, Nicholas C. , XIAO, Dengming , SPENCER, Keith Lee , BENCSIK, Josef R. , LIANG, Jun , SAFINA, Brian , LI, Jun , CHABOT, Christine , BANKA, Anna.L. , WALLACE, Eli. M. , SCHLACHTER, Stephen.T.
IPC分类号： C07D239/70 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D409/12 , C07D409/14 , A61K31/517 , A61P35/00
CPC分类号： C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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2.发明授权HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 有权羟基化PYRIMIDYLCYCLOPENTANE AS AKT蛋白激酶抑制剂
公开(公告)号：EP2247578B1
公开(公告)日：2013-05-22
申请号：EP09700422.0
申请日：2009-01-09
发明人： BENCSIK, Josef R. , BLAKE, James F. , KALLAN, Nicholas C. , MITCHELL, Ian S. , SPENCER, Keith Lee , XIAO, Dengming , XU, Rui , CHABOT, Christine , DO, Steven , LIANG, Jun , SAFINA, Brian , ZHANG, Birong
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00
CPC分类号： C07D239/70
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3.发明公开HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 有权羟丙基吡嗪基胆碱酯酶AKT-PROTEINKINASEINHIBITOREN
公开(公告)号：EP2247578A1
公开(公告)日：2010-11-10
申请号：EP09700422.0
申请日：2009-01-09
发明人： BENCSIK, Josef R. , BLAKE, James F. , KALLAN, Nicholas C. , MITCHELL, Ian S. , SPENCER, Keith Lee , XIAO, Dengming , XU, Rui , CHABOT, Christine , DO, Steven , LIANG, Jun , SAFINA, Brian , ZHANG, Birong
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00
CPC分类号： C07D239/70
摘要： The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.
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4.发明公开
公开(公告)号：EP2049500A1
公开(公告)日：2009-04-22
申请号：EP07799329.3
申请日：2007-07-05
发明人： MITCHELL, Ian S. , BLAKE, James F. , XU, Rui , KALLAN, Nicholas C. , XIAO, Dengming , SPENCER, Keith Lee , BENCSIK, Josef R. , LIANG, Jun , SAFINA, Brian , LI, Jun , CHABOT, Christine , BANKA, Anna.L. , WALLACE, Eli. M. , SCHLACHTER, Stephen.T.
IPC分类号： C07D239/70 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D409/12 , C07D409/14 , A61K31/517 , A61P35/00
CPC分类号： C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：EP2049546B1
公开(公告)日：2010-12-29
申请号：EP07799326.9
申请日：2007-07-05
发明人： MITCHELL, Ian S. , BLAKE, James, F. , XU, Rui , KALLAN, Nicholas C. , XIAO, Dengming , SPENCER, Keith Lee , BENCSIK, Josef R.
IPC分类号： C07D493/04 , A61K31/519 , A61P35/00
CPC分类号： C07D493/04
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供了化合物，包括其拆分的对映异构体，非对映异构体，溶剂合物和药学上可接受的盐，其包括式（I）：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗过度增殖性疾病 作为癌症。
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6.发明公开
公开(公告)号：EP2054418A1
公开(公告)日：2009-05-06
申请号：EP07799336.8
申请日：2007-07-05
发明人： MITCHELL, Ian S. , BLAKE, James F. , XU, Rui , KALLAN, Nicholas C. , XIAO, Dengming , SPENCER, Keith Lee , BENCSIK, Josef R.
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供了化合物，包括其拆分的对映异构体，非对映异构体，溶剂合物和药学上可接受的盐，其包括式（I）：还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和用于治疗过度增殖性疾病 作为癌症。
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7.发明公开
公开(公告)号：EP2049546A1
公开(公告)日：2009-04-22
申请号：EP07799326.9
申请日：2007-07-05
发明人： MITCHELL, Ian S. , BLAKE, James, F. , XU, Rui , KALLAN, Nicholas C. , XIAO, Dengming , SPENCER, Keith Lee , BENCSIK, Josef R.
IPC分类号： C07D493/04 , A61K31/519 , A61P35/00
CPC分类号： C07D493/04
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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8.发明授权DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS 有权Dihydrothienopyrimidines AS AKT蛋白激酶抑制剂
公开(公告)号：EP2054418B1
公开(公告)日：2011-11-09
申请号：EP07799336.8
申请日：2007-07-05
申请人： Array Biopharma Inc.
发明人： MITCHELL, Ian S. , BLAKE, James F. , XU, Rui , KALLAN, Nicholas C. , XIAO, Dengming , SPENCER, Keith Lee , BENCSIK, Josef R.
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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