公开(公告)号：EP1697301A2

公开(公告)日：2006-09-06

申请号：EP04807850.5

申请日：2004-12-20

申请人： Astellas Pharma Inc.

发明人： HATTORI, Kouji, Astellas Pharma Inc ,  TODA, Susumu, Astellas Pharma Inc. ,  IMANISHI, Masashi, Astellas Pharma Inc. ,  ITO, Shinji, Astellas Pharma Inc. ,  WASHIZUKA, Kenichi, Astellas Pharma Inc. ,  ARAKI, Takanobu, Astellas Pharma Inc. ,  SAKURAI, Minoru, Astellas Pharma Inc. ,  TANABE, Daisuke, Astellas Pharma Inc.

IPC分类号： C07C229/56

CPC分类号： C07C229/56 ,  C07C229/38 ,  C07C271/16 ,  C07C311/51 ,  C07C323/63 ,  Y02P20/55

摘要： The present invention relates to a compound formula (I): wherein (II) is (III) or (IV), X is bond, -CH2-, -O- or -NH-, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl) carbamoyl or lower alkanoylsulfamoyl, R8 is -Y-R9, in which Y is bond, -CH2-, -O-, -S-, etc., and R9 is hydrogen, lower alkyl, cyclo (lower) alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.