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公开(公告)号：EP3083616A1
公开(公告)日：2016-10-26
申请号：EP14815838.9
申请日：2014-12-19
发明人： CHESSARI, Gianni , JOHNSON, Christopher Norbert , HOWARD, Steven , DAY, James Edward Harvey , BUCK, Ildiko Maria , GRIFFITHS-JONES, Charlotte Mary , SAXTY, Gordon , TAMANINI, Emiliano , WILSHER, Nicola Elisabeth
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/5377
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：EP2909198A1
公开(公告)日：2015-08-26
申请号：EP13780389.6
申请日：2013-10-18
发明人： CHESSARI, Gianni , JOHNSON, Christopher Norbert , PAGE, Lee William , BUCK, Ildiko Maria , DAY, James Edward Harvey , HOWARD, Steven , SAXTY, Gordon , MURRAY, Christopher William
IPC分类号： C07D403/14 , C07D471/04 , C07D519/00 , A61K31/437 , A61P35/00
CPC分类号： C07D403/14 , C07D471/04 , C07D519/00
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的新的双环杂环化合物：涉及包含所述化合物的药物组合物以及涉及所述化合物在治疗疾病中的用途， 癌症。
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公开(公告)号：EP2699562A1
公开(公告)日：2014-02-26
申请号：EP12717460.5
申请日：2012-04-20
发明人： WOOLFORD, Alison Jo-Anne , HOWARD, Steven , BUCK, Ildiko Maria , CHESSARI, Gianni , JOHNSON, Christopher Norbert , TAMANINI, Emiliano , DAY, James Edward Harvey , CHIARPARIN, Elisabetta , HEIGHTMAN, Thomas Daniel , FREDERICKSON, Martyn , GRIFFITHS-JONES, Charlotte Mary
IPC分类号： C07D401/06 , C07D471/04 , C07D471/10
CPC分类号： C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的双环杂环化合物：或互变异构体或立体化学异构形式，N-氧化物，药学上可接受的盐或其溶剂合物; 其中R1，R2a，R2b，R3a，R3b，R5，R6，R7，R8，R9，p和E如本文所定义; 包括所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。
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公开(公告)号：EP3868747A1
公开(公告)日：2021-08-25
申请号：EP20214100.8
申请日：2012-04-20
发明人： WOOLFORD, Alison Jo-Anne , HOWARD, Steven , BUCK, Ildiko Maria , CHESSARI, Gianni , JOHNSON, Christopher Norbert , TAMANINI, Emiliano , DAY, James Edward Harvey , CHIARPARIN, Elisabetta , HEIGHTMAN, Thomas Daniel , FREDERICKSON, Martyn , GRIFFITHS-JONES, Charlotte Mary
IPC分类号： C07D401/06 , C07D471/04 , C07D471/10
摘要： The invention relates to bicyclic heterocycle compounds of formula (I):
or tautomeric or stereochemically isomeric forms, N -oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R 1 , R 2a , R 2b , R 3a , R 3b , R 5 , R 6 , R 7 , R 8 , R 9 , p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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