公开(公告)号：EP1781647A2

公开(公告)日：2007-05-09

申请号：EP05762253.2

申请日：2005-07-22

申请人： Astex Therapeutics Limited

发明人： BERDINI, Valerio ,  EARLY, Theresa Rachael ,  O'BRIEN, Michael Alistair ,  WOODHEAD, Andrew James ,  WYATT, Paul Graham

IPC分类号： C07D417/12

CPC分类号： C07D275/03 ,  C07D277/56 ,  C07D417/12 ,  C07D417/14

摘要： The invention provides a compound for use in the prophylaxis or treatment of a disease state or condition mediated by a cyclin dependent kinase, the compound having the formula (I): (I) and salts, tautomers, N-oxides or solvates thereof; wherein A is a bond, C=O, NRg(C=O) or O(C=O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; Q is S or CR2; J is S or CH; provided that one of Q and J is S, and the other of Q and J is not S; when Q is S, there is a double bond between the ring carbon atoms “a” and “b” and a double bond between the ring nitrogen N and J; and when J is S, there is a double bond between Q and the ring carbon atom “a” and a double bond between the ring nitrogen N and the ring carbon atom “b”; and R1 to R4 are as defined in the claims.