公开(公告)号：EP1841763A1

公开(公告)日：2007-10-10

申请号：EP05801592.6

申请日：2005-11-07

申请人： AstraZeneca AB

发明人： BENGTSSON, Malena ,  LARSSON, Joakim ,  NIKITIDIS, Grigorios ,  STORM, Peter ,  BAILEY, John Peter, AstraZeneca R & D Alderley ,  GRIFFEN, Edward Jolyon, AstraZeneca R & D Alderley ,  ARNOULD, Jean-Claude AstraZeneca Reims ,  BIRD, Thomas Geoffrey Colerick, AstraZeneca Reims

IPC分类号： C07D417/04 ,  C07D417/14 ,  A61K31/4439 ,  A61P35/00

CPC分类号： C07D417/04 ,  C07D417/14

摘要： The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R1, R2 and R3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.

公开(公告)号：EP1841763B1

公开(公告)日：2010-06-30

申请号：EP05801592.6

申请日：2005-11-07

申请人： AstraZeneca AB

发明人： BENGTSSON, Malena ,  LARSSON, Joakim ,  NIKITIDIS, Grigorios ,  STORM, Peter ,  BAILEY, John Peter, AstraZeneca R & D Alderley ,  GRIFFEN, Edward Jolyon, AstraZeneca R & D Alderley ,  ARNOULD, Jean-Claude AstraZeneca Reims ,  BIRD, Thomas Geoffrey Colerick, AstraZeneca Reims

IPC分类号： C07D417/04 ,  C07D417/14 ,  A61K31/4439 ,  A61P35/00

CPC分类号： C07D417/04 ,  C07D417/14

摘要： The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R1, R2 and R3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.