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公开(公告)号:EP1370245A1
公开(公告)日:2003-12-17
申请号:EP02701873.8
申请日:2002-03-06
申请人: AstraZeneca AB
发明人: DJURLE, Alf , HANSSON, Mikael , SÖDERBOM, Malin
IPC分类号: A61K9/16 , A61K31/138 , A61P9/00
CPC分类号: A61K9/1688 , A61K9/2081 , A61K9/5047
摘要: A method for the preparation of homogenous microparticles containing metoprolol by a fluidized bed process. The microparticles have a size distribution of less than 250 µm and contain at least 80% by weight of metoprolol.
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公开(公告)号:EP1978913B1
公开(公告)日:2013-06-19
申请号:EP07709283.1
申请日:2007-01-22
申请人: AstraZeneca AB
发明人: DJURLE, Alf , WURST, Reiner
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公开(公告)号:EP1978913A1
公开(公告)日:2008-10-15
申请号:EP07709283.1
申请日:2007-01-22
申请人: AstraZeneca AB
发明人: DJURLE, Alf , WURST, Reiner
摘要: The present invention relates to a method for dosing a pharmaceutical product in a packaging machine comprising at least one volumetric dosing unit with a dosing chamber. The method comprises metering a volume of a first component, weighing the first component, introducing the first component into a package and metering a volume of a second component, introduce g the second component into the package and weighing of the package into which the components have being introduced. The invention further relates to a system for dosing a pharmaceutical product in a packaging machine comprising at least one volumetric dosing unit with a dosing chamber. The system comprises at least one volumetric dosing unit for metering a volume of the components. Further, means for introducing the said components into a package and means for weighing the components and the package are comprised. The means for weighing comprises a first weighing unit for weighing the package and the components, and a second weighing unit for weighing the first component after metering the first component by volume and before introducing the first component into the package.
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公开(公告)号:EP1370245B1
公开(公告)日:2005-05-11
申请号:EP02701873.8
申请日:2002-03-06
申请人: AstraZeneca AB
发明人: DJURLE, Alf , HANSSON, Mikael , SÖDERBOM, Malin
IPC分类号: A61K9/16 , A61K31/138 , A61P9/00
CPC分类号: A61K9/1688 , A61K9/2081 , A61K9/5047
摘要: A method for the preparation of homogenous microparticles containing metoprolol by a fluidized bed process. The microparticles have a size distribution of less than 250 µm and contain at least 80% by weight of metoprolol.
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