专利检索 ap:("AstraZeneca AB") AND inv:"JOHANSSON, Lars, George" 第 1 页

1.

发明授权
NOVEL (R)-5-CARBAMOYL-8-FLUORO-3-N,N-DISUBSTITUTED-AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES 失效
标题翻译：烯丙基-8-氟-3-N，N-脱水氨基 - 氨基-3,4-二氢-2H-哒嗪-2-酮

公开(公告)号：EP0725779B1

公开(公告)日：2001-07-11

申请号：EP94931725.9

申请日：1994-10-26

申请人： AstraZeneca AB

发明人： EVENDEN, John, Leslie , HAMMARBERG, Eva, Maria , HANSSON, Hans, Sverker , HELLBERG, Sven, Erik , JOHANSSON, Lars, George , LUNDKVIST, Johan, Rune, Michael , ROSS, Svante, Bertil , SOHN, Daniel, Dungan , THORBERG, Seth, Olov

IPC分类号： C07D311/58 , A61K31/35

CPC分类号： C07D311/58 , A61K31/353 , C07D335/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12

摘要： Compounds of general formula (I), wherein R1 is n-propyl or cyclobutyl; R2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R3 is hydrogen; R4 is hydrogen or methyl; as (R)-enantiomer and in the form of free base or pharmaceutically acceptable salts thereof, process for their preparation, pharmaceutical composition, use of and method of treatment of disorders in CNS.