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1.发明公开NOVEL 5, 7-DISUBSTITUTED [1, 3]THIAZOLO [4, 5-D]PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY 有权NEW 5,7二取代的[1，3]噻唑并[4,5-d]嘧啶-2（3H） - 酮衍生物及其在治疗中的
公开(公告)号：EP2069364A1
公开(公告)日：2009-06-17
申请号：EP07835061.8
申请日：2007-09-27
申请人： AstraZeneca AB
发明人： JOHANSSON, Rolf , KARLSTRÖM, Sofia , KERS, Annika , NORDVALL, Gunnar , REIN, Tobias , SLIVO, Can
IPC分类号： C07D513/04 , A61K31/519 , A61P11/06 , A61P25/00 , A61P9/10
CPC分类号： C07D513/04
摘要： There are disclosed novel 5,7-disubstituted [1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one derivatives of formula (I) wherein R1, R2, R3, R4 and n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.
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2.发明公开NOVEL 5,7-DISUBSTITUTED [1, 3]THIAZOLO [4, 5D]PYRIMIDIN-2 (3H)-AMINE DERIVATIVES AND THEIR USE IN THERAPY 审中-公开NEW 5,7，7二取代[1，3]噻唑并[4,5-d]嘧啶-2（3H）胺衍生物及其在治疗中的用途
公开(公告)号：EP2069365A1
公开(公告)日：2009-06-17
申请号：EP07835062.6
申请日：2007-09-27
申请人： AstraZeneca AB
发明人： JOHANSSON, Rolf , KARLSTRÖM, Sofia , KERS, Annika , NORDVALL, Gunnar , REIN, Tobias , SLIVO, Can
IPC分类号： C07D513/04 , A61K31/519 , A61P11/06 , A61P25/00 , A61P9/10
CPC分类号： C07D513/04
摘要： There are disclosed novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I) wherein R1, R2, R3, R4 and n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.
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3.发明授权NOVEL 5, 7-DISUBSTITUTED [1, 3]THIAZOLO [4, 5-D]PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY 有权NEW 5,7二取代的[1，3]噻唑并[4,5-d]嘧啶-2（3H） - 酮衍生物及其在治疗中的
公开(公告)号：EP2069364B1
公开(公告)日：2011-12-14
申请号：EP07835061.8
申请日：2007-09-27
申请人： AstraZeneca AB
发明人： JOHANSSON, Rolf , KARLSTRÖM, Sofia , KERS, Annika , NORDVALL, Gunnar , REIN, Tobias , SLIVO, Can
IPC分类号： C07D513/04 , A61K31/519 , A61P11/06 , A61P25/00 , A61P9/10
CPC分类号： C07D513/04
摘要： There are disclosed novel 5,7-disubstituted [1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one derivatives of formula (I) wherein R1, R2, R3, R4 and n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.
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