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公开(公告)号：EP1922305A1
公开(公告)日：2008-05-21
申请号：EP06758094.4
申请日：2006-07-31
申请人： AstraZeneca AB
IPC分类号： C07D211/58 , A61K31/4468 , A61K9/72 , A61P11/06
CPC分类号： A61K9/0075 , A61K31/4468 , C07D211/58
摘要： The invention provides N-{2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methylpropyl)oxy]-4-hydroxyphenyl}acetamide furoate or a solvate thereof, pharmaceutical compositions containing the salt or solvate and use of the salt or solvate in therapy.
摘要翻译： 本发明提供N- {2 - [（（2S）-3 - {[1-（4-氯苄基）哌啶-4-基]氨基} -2-羟基-2-甲基丙基）氧基] -4-羟基苯基} 糠酸酯或其溶剂化物，含有该盐或溶剂化物的药物组合物以及该盐或溶剂化物在治疗中的用途。
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公开(公告)号：EP1912944A1
公开(公告)日：2008-04-23
申请号：EP06769591.6
申请日：2006-07-31
申请人： AstraZeneca AB
IPC分类号： C07D211/58 , A61K31/4468 , A61K9/72 , A61P11/06
CPC分类号： C07D211/58 , A61K9/0075 , A61K31/4468
摘要： The invention provides N-{2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methylpropyl)oxy]-4-hydroxyphenyl}acetamide hemi-fumarate or a solvate thereof, pharmaceutical compositions containing the salt or solvate and use of the salt or solvate in therapy.
摘要翻译： 本发明提供N- {2 - [（（2S）-3 - {[1-（4-氯苄基）哌啶-4-基]氨基} -2-羟基-2-甲基丙基）氧基] -4-羟基苯基} 半富马酸盐或其溶剂化物，含有该盐或溶剂化物的药物组合物以及该盐或溶剂化物在治疗中的用途。
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3.发明公开NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开新三环SPIROPIPERIDINVERBINDUNGEN，它们的合成及它们作为趋化因子受体调节剂
公开(公告)号：EP2069355A1
公开(公告)日：2009-06-17
申请号：EP07748335.2
申请日：2007-07-17
申请人： AstraZeneca AB
发明人： ERIKSSON, Tomas , HEMMERLING, Martin , JOSEFSSON, Bo-Göran , IVANOVA, Svetlana , MENSONIDES-HARSEMA, Marguérite , MO, John , PAVEY, John , PIMM, Austen , REUBERSON, James , SCHULZ, Håkan , STRANDBERG, Per
IPC分类号： C07D491/107 , A61K31/438 , A61P11/00 , C07C235/60 , C07D211/48 , C07D303/23
CPC分类号： C07C233/25 , C07C69/92 , C07C235/60 , C07D211/48 , C07D303/23 , C07D491/107
摘要： Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.
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4.发明公开NEW SALT I 审中-公开Benzoatsalz von N- {2 - [（2S）-3 - {[1-（4-氯苄基）哌啶-4-基]氨基} -2-羟基-2-甲基丙基）氧基] -4-羟基苯基}乙酰胺
公开(公告)号：EP1912943A1
公开(公告)日：2008-04-23
申请号：EP06769590.8
申请日：2006-07-31
申请人： AstraZeneca AB
IPC分类号： C07D211/58 , A61K31/4468 , A61K9/72 , A61P11/06
CPC分类号： A61K9/0075 , A61K31/4468 , C07D211/58
摘要： The invention provides N-{2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methylpropyl)oxy]-4-hydroxyphenyl}acetamide benzoate or a solvate thereof, pharmaceutical compositions containing the salt or solvate and use of the salt or solvate in therapy.
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5.发明公开NOVEL PIPERIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS USEFUL FOR THE TREATMENT OF RESPIRATORY DISEASES. 审中-公开新哌啶作为呼吸系统疾病的处理的合适的趋化因子受体调节剂
公开(公告)号：EP1912942A1
公开(公告)日：2008-04-23
申请号：EP06769588.2
申请日：2006-07-31
申请人： AstraZeneca AB
IPC分类号： C07D211/58 , A61K31/4468 , A61P11/00 , A61P11/06
CPC分类号： C07D211/58
摘要： The invention provides compounds of formula wherein m, R1, R2 and R3 are as defined in the specification, salts and polymorphic forms thereof, processes for the preparation of the compounds, salts and polymorphs, pharmaceutical compositions containing these compounds, salts and/or polymorphic forms and their use in therapy.
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