公开(公告)号：EP1802570A1

公开(公告)日：2007-07-04

申请号：EP05790943.4

申请日：2005-10-11

申请人： AstraZeneca AB

发明人： CORNWALL, Philip ,  ENNIS, David, Simon ,  GILES, Melvyn, Edward ,  JENKIN, Shelly, Louise ,  PARKER, Jeremy, Stephen ,  PATEL, Bharti ,  PERKINS, Jacob, Robert, James

IPC分类号： C07C317/22 ,  C07C255/54 ,  C07D231/40 ,  C07D213/80

CPC分类号： C07D231/40 ,  C07C255/54 ,  C07C317/22 ,  C07D213/80

摘要： A process for making a compound of formula (I), said process comprising a) reaction of a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, conversion of X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

摘要翻译： 制备式（I）化合物的方法，所述方法包括a）使式（II）化合物与：i）式（III）化合物通过X2的亲核芳族取代和ii）式 （IV）例如通过亲核芳族取代b）如果需要，将X1转化成羧酸; 和c）将羧酸基团偶联到合适的杂环胺上; 其中所有变量如说明书中所定义。