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1.发明公开FUSED HETROCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC RECEPTOR ANTAGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 有权缩合杂环化合物及其热带METABO受体的胃肠道疾病的治疗拮抗剂
公开(公告)号：EP1716152A2
公开(公告)日：2006-11-02
申请号：EP05713794.5
申请日：2005-02-17
发明人： JOHANSSON, Martin, c/o AstraZeneca R & D , WENSBO, David, c/o AstraZeneca R & D Headquarters , MINIDIS, Alexander, c/o AstraZeneca R & D , STAAF, Karin, c/o AstraZeneca R & D Headquarters , KERS, Annika, c/o AstraZeneca R & D Headquarters , EDWARDS, Louise, c/o NPS Allelix Corp. , ISAAC, Methvin, c/o NPS Allelix Corp. , STEFANAC, Tomislav, c/o NPS Allelix Corp. , SLASSI, Abdelmalik, c/o NPS Allelix Corp. , MCLEOD, Donald, c/o NPS Pharmaceuticals, Inc. , XIN, Tao
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D513/04
摘要： The present invention is directed to compounds of formula: (I); wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, R1, R2, R3, R4, and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds for treating gastrointestinal disorders.
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2.发明授权FUSED HETROCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC RECEPTOR ANTAGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 有权缩合杂环化合物及其热带METABO受体的胃肠道疾病的治疗拮抗剂
公开(公告)号：EP1716152B1
公开(公告)日：2008-07-30
申请号：EP05713794.5
申请日：2005-02-17
申请人： AstraZeneca AB
发明人： JOHANSSON, Martin, c/o AstraZeneca R & D , WENSBO, David, c/o AstraZeneca R & D Headquarters , MINIDIS, Alexander, c/o AstraZeneca R & D , STAAF, Karin, c/o AstraZeneca R & D Headquarters , KERS, Annika, c/o AstraZeneca R & D Headquarters , EDWARDS, Louise, c/o NPS Allelix Corp. , ISAAC, Methvin, c/o NPS Allelix Corp. , STEFANAC, Tomislav, c/o NPS Allelix Corp. , SLASSI, Abdelmalik, c/o NPS Allelix Corp. , MCLEOD, Donald, c/o NPS Pharmaceuticals, Inc. , XIN, Tao
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D513/04
摘要： The present invention is directed to compounds of formula: (I); wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, R1, R2, R3, R4, and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds for treating gastrointestinal disorders.
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