公开(公告)号：EP4434965A1

公开(公告)日：2024-09-25

申请号：EP22932813.3

申请日：2022-04-13

申请人： Asymchem Life Science (Tianjin) Co., Ltd

发明人： HONG, Hao ,  JAMES, Gage ,  XIAO, Yi ,  JIAO, Jianye ,  YAN, Honglei ,  ZHANG, Tao ,  LIU, Bin ,  LIN, Han ,  XIONG, Zhengchang

IPC分类号： C07D207/20

CPC分类号： Y02P20/55 ,  C07D207/20

摘要： The present disclosure discloses a method for continuously synthesizing N-Boc-2,5-dihydropyrrole. The method includes the following steps: cis-1,4 dichloro-2 butene is dissolved in an organic solvent, to prepare solution A; urotropine is dissolved in an organic solvent, to prepare solution B; the solution A and solution B are fed into a first continuous reaction device; a product overflow system of the first continuous reaction device is transferred to a second continuous reaction device, and concentrated hydrochloric acid is fed into the same; a product overflow system of the second continuous reaction device is transferred to a third continuous reaction device, and potassium carbonate is fed into the same; a product overflow system of the third continuous reaction device is transferred to a fourth continuous reaction device, and Boc acid anhydride solution is fed into the same; and a product of the fourth continuous reaction device is subjected to continuous solid-liquid separation, concentration and distillation, to obtain N-Boc-2,5-dihydropyrrole. By using technical solution of the present disclosure, the route involving high-risk materials is avoided, and the production capacity and yield are improved in a continuous manner.