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1.发明公开SCREENING COMPOUNDS FOR THE ABILITY TO ALTER THE PRODUCTION OF AMYLOID-BETA PEPTIDE 失效化合物构成的能力，β-淀粉样肽的生产影响及其筛选
公开(公告)号：EP0906577A1
公开(公告)日：1999-04-07
申请号：EP97932208.0
申请日：1997-06-18
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18 , G01N33/6896 , G01N2333/4709 , G01N2500/00 , G01N2500/10 , G01N2800/2821
摘要： This invention provides methods of screening compounds for their ability to alter the production of Aβ (x≥41) alone or in combination with Aβ (x≤40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ (x≤40) and Aβ (x≥41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.
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2.发明授权SCREENING COMPOUNDS FOR THE ABILITY TO ALTER THE PRODUCTION OF AMYLOID-BETA PEPTIDE 失效化合物构成的能力，β-淀粉样肽的生产影响及其筛选
公开(公告)号：EP0906577B2
公开(公告)日：2012-07-18
申请号：EP97932208.8
申请日：1997-06-18
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18 , G01N33/6896 , G01N2333/4709 , G01N2500/00 , G01N2500/10 , G01N2800/2821
摘要： This invention provides methods of screening compounds for their ability to alter the production of Aβ (x≥41) alone or in combination with Aβ (x≤40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ (x≤40) and Aβ (x≥41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.
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3.发明公开METHOD OF SUPPRESSING BETA-AMYLOID-RELATED CHANGES IN ALZHEIMER'S DISEASE 有权变化中的β淀粉样蛋白阿尔茨海默病CONNECTION抑
公开(公告)号：EP1033998A1
公开(公告)日：2000-09-13
申请号：EP98961894.7
申请日：1998-12-03
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K38/2026 , A61K2300/00
摘要： Methods are provided for treating or preventing Alzheimer's disease comprising mucosally administering β-amyloid peptide or a fragment or analog thereof in an oral or other mucosal dosage form. Also disclosed herein are pharmaceutical formulation or dosage forms for use in these methods.
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4.发明授权SCREENING COMPOUNDS FOR THE ABILITY TO ALTER THE PRODUCTION OF AMYLOID-BETA PEPTIDE 失效化合物构成的能力，β-淀粉样肽的生产影响及其筛选
公开(公告)号：EP0906577B1
公开(公告)日：2008-09-03
申请号：EP97932208.8
申请日：1997-06-18
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18 , G01N33/6896 , G01N2333/4709 , G01N2500/00 , G01N2500/10 , G01N2800/2821
摘要： This invention provides methods of screening compounds for their ability to alter the production of Aβ (x≥41) alone or in combination with Aβ (x≤40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ (x≤40) and Aβ (x≥41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.
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