公开(公告)号：EP2493459A1

公开(公告)日：2012-09-05

申请号：EP10827563.7

申请日：2010-10-29

申请人： Aton Pharma, Inc. ,  Louisiana State University Agricultural And Mechanical College

发明人： JACOB, Jean Theresa ,  HALLORAN, Kevin John ,  MCKEE, Yuri

IPC分类号： A61K9/50 ,  C08L1/26

CPC分类号： A61K9/0051 ,  A61K31/00 ,  A61K31/133 ,  A61K31/216 ,  A61K31/7036 ,  A61K38/12 ,  A61K38/13 ,  A61K47/36 ,  C08L1/284

摘要： A method of forming an ocular delivery device includes exposing a solid, shaped cellulose polymer to a solution including an active pharmaceutical ingredient (API) and a solvent capable of solubilizing the API, wherein the polymer absorbs at least a portion of the solution, including the API and solvent. The method may further include removing at least a portion of the absorbed solvent from the polymer by allowing the absorbed solvent to evaporate from the polymer or by drying the polymer. A variety of cellulose polymers may be used, including hydroxypropyl cellulose. A variety of APIs may be used, including Cyclosporine, Tobramycin and Vancomycin. Ocular delivery devices prepared by the methods may be used to treat a variety of eye disorders.

公开(公告)号：EP2493459B1

公开(公告)日：2016-08-24

申请号：EP10827563.7

申请日：2010-10-29

申请人： Aton Pharma, Inc. ,  Louisiana State University Agricultural And Mechanical College

发明人： JACOB, Jean Theresa ,  HALLORAN, Kevin John ,  MCKEE, Yuri

IPC分类号： A61K9/50 ,  C08L1/26

CPC分类号： A61K9/0051 ,  A61K31/00 ,  A61K31/133 ,  A61K31/216 ,  A61K31/7036 ,  A61K38/12 ,  A61K38/13 ,  A61K47/36 ,  C08L1/284