专利检索 ap:("Aurin Biotech Inc.") AND inv:"MCGEER, Patrick" 第 1 页

1.

发明公开
SELECTIVE INHIBITION OF THE MEMBRANE ATTACK COMPLEX OF COMPLEMENT AND C3 CONVERTASE BY LOW MOLECULAR WEIGHT COMPONENTS OF THE AURIN TRICARBOXYLIC ACID SYNTHETIC COMPLEX 审中-公开
标题翻译：补体和C3转化BY低分子量组分合成金精三复杂的膜攻击复合物的选择性抑制

公开(公告)号：EP2872130A1

公开(公告)日：2015-05-20

申请号：EP12880850.8

申请日：2012-07-13

申请人： Aurin Biotech Inc.

发明人： MCGEER, Patrick , LEE, Moonhee , GUO, Jian-Ping , SCHWAB, Claudia

IPC分类号： A61K31/194 , A61P37/02 , C12N9/64

CPC分类号： C12Y304/21043 , A61K31/194 , C12N9/6424 , Y02A50/411

摘要： Selective inhibition of the membrane attack complex of complement in a mammalian species, preferably human, with components of the aurin tricarboxylic acid complex of less than 1 kilodalton in molecular weight. Preferred inhibitors are aurin tricarboxylic acid, aurin quadracarboxylic acid and aurin hexacarboxylic acid. Preferred disease to be treated by elective inhibition of the membrane attack complex of complement are age-related macular degeneration, Alzheimer's disease, atherosclerosis, rheumatoid arthritis, paroxysmal nocturnal hemoglobinemia, malaria infection and multiple sclerosis.