公开(公告)号：EP1339655A1

公开(公告)日：2003-09-03

申请号：EP01998521.7

申请日：2001-11-29

申请人： Avecia Limited

发明人： WILLIAMS, Jonathon, Michael,J.University of Bath ,  BUBERT, ChristianUniversity of Bath ,  BROWN, Stephen, Martin ,  BLACKER, Andrew, John

IPC分类号： C07B53/00 ,  C07C29/143 ,  C07C33/18 ,  C07C33/20 ,  C07C33/46 ,  C07C35/32 ,  C07C41/26 ,  C07C43/178 ,  C07M7/00 ,  B01J31/22 ,  C07C311/18 ,  C07C311/20

CPC分类号： B01J31/226 ,  B01J31/1805 ,  B01J31/2217 ,  B01J31/2295 ,  B01J31/28 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2540/22 ,  B01J2540/325 ,  B01J2540/34 ,  B01J2540/345 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/143 ,  C07C311/18 ,  C07C311/20 ,  C07C2602/08 ,  C07D339/04 ,  C07F17/02 ,  C07C33/46 ,  C07C35/32 ,  C07C33/18 ,  C07C33/22

摘要： A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydrocarbyl group, a sulphonated perhalogenated hydrocarbyl group, or an optionally substituted sulphonated heterocyclyl group. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcolols, particularly those comprising chiral centres. The hydrogen donor is advantageously a secondary alcohol or a mixture of thiethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.

摘要翻译： 提供催化转移氢化方法。 在该方法中使用的催化剂是金属烃基络合物，其与由至少一个选自任选取代的磺化烃基，磺化的全卤代烃基或任选取代的磺化杂环基的基团配位的二齿配体配位。 优选的金属包括铑，钌和铱。 优选的二齿配体是二胺和氨基醇，特别是包含手性中心的那些。 氢供体有利地是仲醇或三乙胺和甲酸的混合物。 该方法可用于转移氢化酮和亚胺，其优选是前手性的。 还提供了用于这种方法的催化剂。