公开(公告)号：EP4134363A1

公开(公告)日：2023-02-15

申请号：EP21785575.8

申请日：2021-04-09

申请人： Aventi Inc.

发明人： KWON, Ki-Sun ,  LEE, Younglang ,  YOON, Jong Hyun ,  LEE, Seung-Min ,  JEON, Chang Hoon ,  HA, Tai Hwan ,  JEONG, Do Yeun

IPC分类号： C07C215/54 ,  C07C211/03 ,  A61K31/135 ,  A61K31/133 ,  A61P21/00 ,  C12N5/077 ,  A23L33/10

摘要： The present invention relates to a pharmaceutical composition for preventing or treating muscular weakness-related diseases, comprising alverine, 4-hydroxy alverine, a derivative thereof, or a pharmaceutically acceptable salt thereof. When myoblasts are treated with the alverine, 4-hydroxy alverine, derivative thereof, or pharmaceutically acceptable salt thereof of the present invention, differentiation into myotubes is promoted. Therefore, the alverine, 4-hydroxy alverine, derivative thereof, or pharmaceutically acceptable salt thereof according to the present invention can be effectively used in the promotion of differentiation of myoblasts and the prevention or treatment of muscular weakness-related diseases.