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1.发明授权OLIGONUCLEOTIDES INHIBANT L'EXPRESSION DE LA PROTEINE OB-RGRP ET PROCEDE DE DETECTION DE COMPOSES MODIFIANT L'INTERACTION ENTRE LES PROTEINES DE LA FAMILLE DE OB-RGRP ET LE RECEPTEUR DE LA LEPTINE 有权寡核苷酸，其中蛋白质OB Rgrp INHIBIT于检测化合物的表达，和方法蛋白之间的相互作用从OB Rgrp家庭和瘦素受体MODIFY
公开(公告)号：EP1594964B1
公开(公告)日：2012-04-11
申请号：EP04709264.8
申请日：2004-02-09
申请人： Aventis Pharma S.A. , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： JOCKERS, Ralf , COUTURIER, Cyril , UHLMANN, Eugen
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/351 , C12N2310/53 , G01N2333/715 , C12N2310/3521
摘要： The invention relates to oligonucleotides which inhibit the expression of the OB-RGRP protein and use thereof for the prevention and/or treatment of diseases related to leptin. The invention further relates to a method for detection of compounds modifying the interaction between the proteins of the OB-RGRP family and the leptin receptor. Said detection can be achieved by means of the energy transfer between the fusion proteins comprising said proteins and proteins which are donors and acceptors of energy.
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2.发明公开OLIGONUCLEOTIDES INHIBANT L'EXPRESSION DE LA PROTEINE OB-RGRP ET PROCEDE DE DETECTION DE COMPOSES MODIFIANT L'INTERACTION ENTRE LES PROTEINES DE LA FAMILLE DE OB-RGRP ET LE RECEPTEUR DE LA LEPTINE 有权寡核苷酸，其中蛋白质OB Rgrp INHIBIT于检测化合物的表达，和方法蛋白之间的相互作用从OB Rgrp家庭和瘦素受体MODIFY
公开(公告)号：EP1594964A2
公开(公告)日：2005-11-16
申请号：EP04709264.8
申请日：2004-02-09
申请人： Aventis Pharma S.A. , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： JOCKERS, Ralf , COUTURIER, Cyril , UHLMANN, Eugen
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/351 , C12N2310/53 , G01N2333/715 , C12N2310/3521
摘要： The invention relates to oligonucleotides which inhibit the expression of the OB-RGRP protein and use thereof for the prevention and/or treatment of diseases related to leptin. The invention further relates to a method for detection of compounds modifying the interaction between the proteins of the OB-RGRP family and the leptin receptor. Said detection can be achieved by means of the energy transfer between the fusion proteins comprising said proteins and proteins which are donors and acceptors of energy.
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公开(公告)号：EP4146197A1
公开(公告)日：2023-03-15
申请号：EP21723253.7
申请日：2021-05-04
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Université Paris Cité
发明人： JOCKERS, Ralf , CECON, Erika , DAM, Julie
IPC分类号： A61K31/4045 , A61K31/165 , A61K31/343 , A61K45/06 , A61P31/14
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