专利检索 ap:("Aventis Pharmaceuticals Inc.") AND inv:"LY, Cuong, Q." 第 1 页

1.

发明授权
PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE 失效
标题翻译：吡唑并（3,4-G）喹喔啉ALS PDGF受体蛋白酪氨酸激酶抑制剂

公开(公告)号：EP0779889B1

公开(公告)日：2004-06-23

申请号：EP95932446.8

申请日：1995-09-06

申请人： Aventis Pharmaceuticals Inc.

发明人： MYERS, Michael, R. , PERSONS, Paul, E. , LY, Cuong, Q. , SPADA, Alfred, P.

IPC分类号： C07D487/04 , A61K31/495

CPC分类号： C07D487/04

摘要： This invention relates to pyrazolo[3,4-g]quinoxaline compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, compounds of this invention are novel as selective inhibitors of the PDGF-R protein tyrosine kinase and can be applied as potential therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation. Further, the present invention provides pharmaceutical compositions and a method for treating such disorders comprising the administration to a patient of a PDGF receptor inhibiting effective amount of a pyrazolo[3,4-g]quinoxaline compound exhibiting protein tyrosine kinase inhibition activity. Processes for the preparation of pyrazolo[3,4-g]quinoxaline compounds.