公开(公告)号：EP1123342A1

公开(公告)日：2001-08-16

申请号：EP99945981.1

申请日：1999-08-14

申请人： Axiva GmbH

发明人： BENGS, Holger ,  GRANDE, Jürgen

IPC分类号： C08J3/14 ,  C08L3/12

CPC分类号： A61K9/5161 ,  A61K9/1652 ,  A61K9/5192 ,  C08J3/14 ,  C08J2305/00 ,  C08L3/12 ,  C08L5/00 ,  Y10T428/2982

摘要： The invention relates to a method for the production of spherical microparticles consisting totally or partly of at least one water-insoluble polysaccharide, wherein the at least one water-insoluble polysaccharide is dissolved in a solvent or solvent mixture, the solution thus formed is introduced into a precipitating agent or precipitating agent mixture, the mixture obtained is optionally cooled and the formed microparticles are separated. The invention is characterized in that the water-insoluble polysaccharide is selected from a polyglucan containing branches with a degree of branching higher than zero and no higher than 8 % and a mixture of a polyglucan containing branches and a linear polysaccharide, wherein the proportion of polyglucan containing branches in the mixture is at the most 30 % by weight in relation to the overall weight of the polysaccharide and the polyglucan.

公开(公告)号：EP1062259A1

公开(公告)日：2000-12-27

申请号：EP99908935.2

申请日：1999-02-20

申请人： Axiva GmbH

发明人： BENGS, Holger ,  SCHÖNFELD, Axel ,  BÖHM, Gitte ,  WEIS, Siegfried ,  CLAUSS, Joachim

IPC分类号： C08G63/60

CPC分类号： A61K47/34 ,  C05G3/0047 ,  C08G63/60

摘要： The invention relates to biodegradable polycondensates, to the production of said polycondensates, and to their use for releasing specific substances. The polycondensates are derived from at least three components chosen from the following group: a) dianhydrohexites b) bivalent (polyvalent) organic carboxylic acids and c) polyvalent organic carboxylic acids which, in addition to two carboxylic acid functions, have at least one other, optionally capped, i.e. OH and/or COOH function.

公开(公告)号：EP1069914A1

公开(公告)日：2001-01-24

申请号：EP99919217.2

申请日：1999-04-08

申请人： Axiva GmbH

发明人： BENGS, Holger ,  SCHUTH, Silke ,  GRANDE, Jürgen ,  BÖHM, Gitte ,  SCHNELLER, Arnold

IPC分类号： A61K47/36 ,  A61K9/20 ,  A61K31/70 ,  A61K31/52 ,  A61K31/40

CPC分类号： A61K9/2081 ,  A61K9/1652

摘要： The invention relates to a controlled release tablet which in part or as a whole contains water-insoluble linear polysaccharides, preferably the polysaccharide poly(1,4-α-D-glycan), in the form of microparticles, as retardation material. Said tablet is also capable of the controlled release of an active agent.