公开(公告)号：EP0321562A4

公开(公告)日：1990-06-05

申请号：EP87904113

申请日：1987-06-25

申请人： BANYU PHARMA CO LTD

发明人： NAKAGAWA SUSUMU ,  USHIJIMA RYOSUKE ,  NAKANO FUMIO ,  YAMADA KOJI ,  MANO EIICHI

IPC分类号： A61K31/545 ,  C07D501/46

CPC分类号： A61K31/545

公开(公告)号：EP0346465A4

公开(公告)日：1989-08-16

申请号：EP87902727

申请日：1987-04-14

申请人： BANYU PHARMA CO LTD

发明人： NAKAGAWA SUSUMU ,  MITOMO RYUJI ,  YAMADA KOJI ,  OTAKE NORIKAZU ,  NAKANO FUMIO ,  ASAI AKIRA ,  KUROYANAGI SATORU ,  TANAKA YOSHIHARU ,  ISHIKAWA MORIAKI ,  USHIJIMA RYOSUKE

IPC分类号： A61K31/545 ,  C07D235/28 ,  C07D263/46 ,  C07D263/58 ,  C07D271/10 ,  C07D271/113 ,  C07D277/20 ,  C07D277/36 ,  C07D277/40 ,  C07D277/56 ,  C07D285/12 ,  C07D285/125 ,  C07D501/22 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46

CPC分类号： C07D263/58 ,  C07D235/28 ,  C07D263/46 ,  C07D271/113 ,  C07D277/36 ,  C07D277/56 ,  C07D277/587 ,  C07D285/125 ,  Y02P20/55

摘要： Compounds represented by general formula (I), [wherein R represents a hydrogen atom, a carboxyl protective group or an anionic charge, Q represents a hydrogen atom, a halogen atom, a hydroxy group, an acetoxy group, a carbamoyloxy group, an azido group, an optionally substituted quaternary ammonio group, or an optionally substituted 5- or 6-membered aromatic heterocyclic thio group containing at least one hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom (additionally, the aromatic hetero ring being optionally bound to a benzene ring or a hetero cyclic ring)], nontoxic salts thereof or nontoxic esters thereof capable of being physiologically hydrolized, process for their preparation, and antibacterial agent containing the compound as an effective ingredient. Further, compounds represented by general formula (III), (wherein R3 represents a hydrogen atom or an amino protective group, and R4 and R5, which may be the same or different, each represents a hydrogen atom or a carboxyl protective group) or their salts and process for their preparation.

公开(公告)号：EP0781773A4

公开(公告)日：1997-12-29

申请号：EP95931419

申请日：1995-09-14

申请人： BANYU PHARMA CO LTD

发明人： NAKAGAWA SUSUMU ,  OTAKE NORIKAZU ,  KIYONAGA HIDEO ,  YAMADA KOJI ,  JONA HIDEKI ,  OKADA SHIGEMITSU ,  OGAWA MASAYUKI ,  IMAMURA HIDEAKI ,  USHIJIMA TARO ,  NAKANO MASATO

IPC分类号： C07D477/20 ,  A61K31/40 ,  A61K31/44 ,  A61K31/495 ,  A61K31/55

CPC分类号： C07D477/20

摘要： A compound represented by general formula (I), a process for producing the same, and the use thereof as an antibacterial wherein R1 either represents hydrogen or lower alkyl, or forms a heterocyclic ring together with R3; R2 represents hydrogen, ester residue, alkali metal or anionic charge; and R?3 and R4¿ represent each independently hydrogen or a hydrocarbon group which may bear a heteroatom selected from among oxygen, sulfur and nitrogen, or R?3 and R4¿ are combined together with the nitrogen atom to which they are bonded to form a heterocyclic group.

摘要翻译： 通式（I）表示的化合物，其制备方法及其作为抗菌剂的用途，其中R1或者表示氢或者低级烷基，或者与R3一起形成杂环; R2代表氢，酯残基，碱金属或阴离子电荷; R 3和R 4'各自独立地代表氢或可带有选自氧，硫和氮的杂原子的烃基，或者R 3和R 4'与它们所键合的氮原子一起形成 杂环基团。

公开(公告)号：EP0747381A4

公开(公告)日：1997-04-02

申请号：EP95909978

申请日：1995-02-24

申请人： BANYU PHARMA CO LTD

发明人： NAKAGAWA SUSUMU ,  FUKATSU HIROSHI ,  USHIJIMA RYOSUKE

IPC分类号： A61K31/407 ,  A61K31/695 ,  A61P31/04 ,  C07D477/20 ,  C07D519/06 ,  C07F7/10 ,  C07D477/00

CPC分类号： C07D477/20

摘要： A compound represented by general formula (I), a medicinally acceptable salt or ester thereof, a process for producing the same, and an antibacterial containing the same as the active ingredient: wherein R1 represents hydrogen or lower alkyl; R2 represents hydrogen or a negative charge; R3 represents hydrogen or lower alkyl; Ar represents lower alkyl, lower alkylsulfamoyl, etc. (each of which may be substituted by hydroxyl, di (lower alkyl) sulfonyl, etc.), or phenyl, naphthyl or a group of formula α or β (each of which may be substituted by hydroxyl, di (lower alkyl) sulfamoyl, etc.), wherein A¿4? and A5 represent each a single bond, -NHSO2-, etc., and Het represents pyrrolinyl, 1,4-diazabicyclo[2.2.2]octanyl, etc. (each of which may be substituted by hydroxyl, carbamoylated lower alkyl, etc.); A1, A2 and A3 represent each a single bond or lower alkylene which may be substituted by lower alkyl, lower alkylsulfamoyl, etc. (each of which may be substituted by hydroxyl, di(lower alkyl)sulfamoyl, etc.) or may be substituted by pyridyl, pyridinio, etc. (each of which may be substituted by lower alkyl, carbamoylated lower alkyl, etc.); and W represents sulfur, a single bond, etc.