公开(公告)号：EP1813613A1

公开(公告)日：2007-08-01

申请号：EP05803283.0

申请日：2005-11-07

申请人： BANYU PHARMACEUTICAL CO., LTD.

发明人： SATO, Y., c/o BANYU PHARMACEUTICAL CO., LTD. ,  KURIHARA, H., c/o BANYU PHARMACEUTICAL CO., LTD. ,  KAMIJO, K., c/o BANYU PHARMACEUTICAL CO., LTD. ,  ONOZAKI, Y., c/o BANYU PHARMACEUTICAL CO., LTD. ,  TSUJINO, T., c/o BANYU PHARMACEUTICAL CO., LTD. ,  SUGIMOTO, T., c/o BANYU PHARMACEUTICAL Co., LTD. ,  WATANABE, A., c/o BANYU PHARMACEUTICAL CO., LTD. ,  MITSUYA, M., c/o BANYU PHARMACEUTICAL CO., LTD. ,  KOMATANI, H., c/o BANYU PHARMACEUTICAL CO., LTD

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/5377 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to a compound represented by the Formula [I]:

Wherein:
the A ring is a 5-membered aromatic heterocyclic group containing at least one hetero atom selected from a nitrogen atom, and the like; A 1 and A 2 , are each a nitrogen atom, and the like; X 2 , X 3 , X 4 , and X 5 are all carbon atoms, or alternatively any one of X 2 , X 3 , X 4 , and X 5 is a nitrogen atom and the rest are all carbon atoms; R 1 is a hydrogen atom, or the like; R 2 , R 3 , R 4 , and R 5 , are each a hydrogen atom, or the like; R 6 and R 6 ', are each a hydrogen atom, and the like; R 7 is an aryl group and the like; and R 8 is an amino group or a hydroxy group,
or a pharmaceutically acceptable salt or ester thereof.

摘要翻译： 本发明涉及由式[I]表示的化合物：其中：A环是含有至少一个选自氮原子的杂原子的5元芳族杂环基等; A 1和A 2各自为氮原子等; X 2，X 3，X 4和X 5都是碳原子，或者任选地，X 2，X 3，X 4和X 5是氮原子，其余全部是碳原子; R 1是氢原子等; R 2，R 3，R 4和R 5各自为氢原子等; R 6和R 6'各自为氢原子等; R 7是芳基等; R 8为氨基或羟基，或其药学上可接受的盐或酯。