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    PHENYLPYRIDONE DERIVATIVE
    1.
    发明授权
    PHENYLPYRIDONE DERIVATIVE 有权
    苯基吡啶酮衍生物

    公开(公告)号：EP1921065B1

    公开(公告)日：2010-10-20

    申请号：EP06797001.2

    申请日：2006-08-23

    申请人： BANYU PHARMACEUTICAL CO., LTD.

    发明人： NAYA, Akira ,  SAKAMOTO, Toshihiro ,  HAGA, Yuji ,  OTAKE, Norikazu

    IPC分类号： C07D213/64 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61P1/00 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P7/08 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P15/06

    CPC分类号： C07D213/69 ,  C07D213/64 ,  C07D401/10 ,  C07D413/10

    摘要： A compound represented by the formula (I) is contained as an active ingredient: wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like, or R1 together with a nitrogen atom to which L, Z2 and R1 are attached may form an aliphatic nitrogenated heterocyclic group and R1 and R2 together with a nitrogen atom to which they are attached may form an aliphatic nitrogenated heterocyclic group; X represents a methine group or a nitrogen atom; Y represents -CH2-O-, -CH=CH- or the like; Z1 represents a single bond, a C1-4 alkylene group or the like; Z2 represents a single bond or a C1-4 alkylene group; L represents a methylene group, a C3-8 cycloalkylene group or the like; and Ar represents an aromatic carbocyclic group or the like. The compound is useful as a pharmaceutical for a central nerves system disease, a cardiovascular disease or a metabolic disease.

    摘要翻译： 含有由式（I）表示的化合物作为活性成分：其中R 1和R 2独立地表示氢原子，低级烷基等，或R 1与连接有L，Z 2和R 1的氮原子一起 可以形成脂肪族含氮杂环基，并且R 1和R 2与它们所连接的氮原子一起可以形成脂肪族含氮杂环基; X代表次甲基或氮原子; Y表示-CH 2 -O - ， - CH = CH-等; Z1表示单键，C1-4亚烷基等; Z2表示单键或C1-4亚烷基; L表示亚甲基，C 3-8亚环烷基等; Ar表示芳族碳环基团等。 该化合物可用作中枢神经系统疾病，心血管疾病或代谢疾病的药物。

    PHENYLPYRIDONE DERIVATIVE
    2.
    发明公开
    PHENYLPYRIDONE DERIVATIVE 有权
    PHENYLPYRIDONDERIVAT

    公开(公告)号：EP1921065A1

    公开(公告)日：2008-05-14

    申请号：EP06797001.2

    申请日：2006-08-23

    申请人： BANYU PHARMACEUTICAL CO., LTD.

    发明人： NAYA, Akira ,  SAKAMOTO, Toshihiro ,  HAGA, Yuji ,  OTAKE, Norikazu

    IPC分类号： C07D213/64 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61P1/00 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P7/08 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P15/06

    CPC分类号： C07D213/69 ,  C07D213/64 ,  C07D401/10 ,  C07D413/10

    摘要： A compound represented by the formula (I) is contained as an active ingredient:

    wherein R 1 and R 2 independently represent a hydrogen atom, a lower alkyl group or the like, or R 1 together with a nitrogen atom to which L, Z 2 and R 1 are attached may form an aliphatic nitrogenated heterocyclic group and R 1 and R 2 together with a nitrogen atom to which they are attached may form an aliphatic nitrogenated heterocyclic group; X represents a methine group or a nitrogen atom; Y represents -CH 2 -O-, -CH=CH- or the like; Z 1 represents a single bond, a C 1-4 alkylene group or the like; Z 2 represents a single bond or a C 1-4 alkylene group; L represents a methylene group, a C 3-8 cycloalkylene group or the like; and Ar represents an aromatic carbocyclic group or the like. The compound is useful as a pharmaceutical for a central nerves system disease, a cardiovascular disease or a metabolic disease.

    摘要翻译： 作为活性成分，含有式（I）表示的化合物：其中，R 1和R 2分别独立地表示氢原子，低级烷基等，或者R 1与氮原子一起，L，Z 2 R 1可以形成脂族氮杂环基，R 1和R 2与它们所连接的氮原子一起形成脂族氮杂环基; X表示次甲基或氮原子; Y表示-CH 2 -O-，-CH = CH-等; Z 1表示单键，C 1-4亚烷基等; Z 2表示单键或C 1-4亚烷基; L表示亚甲基，C 3-8亚环烷基等; Ar表示芳香族碳环基等。 该化合物可用作中枢神经系统疾病，心血管疾病或代谢疾病的药物。