公开(公告)号：EP1905769A1

公开(公告)日：2008-04-02

申请号：EP06781274.3

申请日：2006-07-12

申请人： BANYU PHARMACEUTICAL CO., LTD.

发明人： OGINO, Yoshio c/o Tsukuba Research Institute ,  NONOSHITA,Katsumasa c/o Tsukuba Research Institute ,  NISHIMURA, Teruyuki c/o Tsukuba Research Institute ,  EIKI, Jun-ichi c/o Tsukuba Research Institute

IPC分类号： C07D405/14 ,  A61K31/4439 ,  A61K31/497 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00 ,  C07D409/14 ,  C07D413/14

CPC分类号： C07D409/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14

摘要： Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I):

(wherein X 1 to X 4 represent a carbon atom, etc., ring A represents a 5- or 6-membered heteroaryl having from 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom, X 5 represent an oxygen atom, etc., X represent a carbon atom, etc., Het represents a 5- or 6-membered aliphatic hetero ring, R 1 represents aryl, etc., R 2 represents formyl, etc., R 3 represents -C 1-6 alkyl, etc.), as well as their pharmaceutically acceptable salts.

摘要翻译： 具有葡糖激酶活化作用并且可用作糖尿病治疗的化合物，其由下式（I）表示：（其中X 1至X 4表示碳原子等，环A表示5-或6-元杂芳基 具有1至4个选自氮原子，硫原子和氧原子的杂原子，X 5表示氧原子等，X表示碳原子等，Het表示5-或 6元脂肪族杂环，R 1表示芳基等，R 2表示甲酰基等，R 3表示-C 1-6烷基等）及其药学上可接受的盐。