公开(公告)号：EP0915908A1

公开(公告)日：1999-05-19

申请号：EP97934502.0

申请日：1997-07-21

申请人： BASF AKTIENGESELLSCHAFT

发明人： BARLOZZARI, Teresa ,  HAUPT, Andreas ,  JANSSEN, Bernd ,  GRIESINGER, Christian ,  BELIK, Daniel ,  BORETZKY, Michael ,  PETTIT, George, Robert

IPC分类号： A61K38 ,  A61P1 ,  A61P11 ,  A61P15 ,  A61P35 ,  C07K7

CPC分类号： C07K7/02 ,  A61K38/00

摘要： The present invention provides anti-tumor peptides of the Formula (I), A-B-N(CH3)-CHD-CH(OCH3)-CH2CO-Pro-Pro-K, and the acid salts thereof. A is an amino acid residue of the formula (CH3)2N-CHX-CO, wherein X is a normal or branched alkyl group. B is an amino acid residue selected from the group consisting of valyl, isoleucyl, leucyl, and 2-t-butylglycyl. D is a normal or branched C3-C4-alkyl group. K is a t-butoxy group or a substituted amino group. An additional embodiment of the present invention is a method for treating a malignancy in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound or compounds of Formula (I) in a pharmaceutically acceptable composition.

公开(公告)号：EP0920325A3

公开(公告)日：2003-06-04

申请号：EP97918936.2

申请日：1997-07-21

申请人： BASF AKTIENGESELLSCHAFT

发明人： BARLOZZARI, Teresa ,  HAUPT, Andreas ,  JANSSEN, Bernd ,  GRIESINGER, Christian ,  BELIK, Daniel ,  BORETZKY, Michael

IPC分类号： A61K38/07

CPC分类号： C07K5/0205 ,  A61K38/00